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ENDOTOXIN-NONRESPONSIVE MODEL ANIMAL achieved

Foreign code F110004408
File No. E07202CA
Posted date Jul 15, 2011
Country Canada
Application number 2540173
Gazette No. 2540173
Gazette No. 2540173
Date of filing Sep 29, 2004
Gazette Date Apr 7, 2005
Gazette Date Jul 17, 2012
Priority data
  • P2003-338013 (Sep 29, 2003) JP
Title ENDOTOXIN-NONRESPONSIVE MODEL ANIMAL achieved
Abstract

The present invention is to provide a non-human animal model non-responsive especially to endotoxin being a Gram-negative bacteria cell wall fraction, which is useful to elucidate the function of TIR domain-containing TRIF-related adaptor molecule (TRAM)

and a method for screening substances promoting or suppressing responses to ligands recognized by TLR4 with the use of the non-human animal model non-responsive to endotoxin

and the like. Mice non-responsive to the endotoxin wherein a part or a whole of Tram genes on their chromosome are deleted, the function to express TRAM which is expressed in wild-types is lacked, and the responsiveness to ligands recognized by TLR4 is specifically impaired

is used for screening substances promoting or suppressing responses to ligands recognized by TLR4.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • YAMAMOTO, MASAHIRO,
  • AKIRA, SHIZUO
IPC(International Patent Classification)
Reference ( R and D project ) ERATO AKIRA Innate Immunity AREA
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