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Therapeutic drug using antibody-presenting hollowprotein nanoparticles and hollow protein nanoparticles achieved

Foreign code F110004964
File No. P023P03KR
Posted date Jul 28, 2011
Country Republic of Korea
Application number 20047015430
Gazette No. 20040105815
Gazette No. 1006358700000
Date of filing Sep 24, 2004
Gazette Date Dec 16, 2004
Gazette Date Oct 12, 2006
International application number PCT/JP2003/003694
International publication number WO2003/082330
Date of international filing Mar 26, 2003
Date of international publication Oct 9, 2003
Priority data
  • P2002-097424 (Mar 29, 2002) JP
  • P2003-045088 (Feb 21, 2003) JP
Title Therapeutic drug using antibody-presenting hollowprotein nanoparticles and hollow protein nanoparticles achieved
Abstract As the medicament using the protein hollow nano particle presented the antibody to the specific cell or the organization, treatment method using the medicine and this medicine in which the animal experiment recognizes the therapeutic effect in fact are provided. In the hollow nano particle consisting of protein (the HBsAg which for example is mutated in order to be the infection nature which confronts the original the cell going sterile and is mutated in order to additionally present the antibody) having the ability to form grains, the cell introduction material (the herpes simplex virus originated thymidine kinase gene called for example, the gene for the cancer treatment) for the disease treating is included. The antibody including the cancer specific antibody etc. is indicated in the particle's surface described in the above. Recognizes clearly the molecule existing in the specific cancer cell surface as the antigen.
The cell introduction material for the protein having the protein hollow nano particle, the antibody presentation, and the ability to form grains, the mutation, deletion, the disease treating.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • KURODA,Shunichi
  • TANIZAWA,Katsuyuki
  • KONDO,Akihiko
  • UEDA,Masakazu
  • SENO,Masaharu
  • OKAJIMA,Toshihide
IPC(International Patent Classification)
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