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Hapten compound and antibody

Foreign code F110004980
File No. RX03P55WO
Posted date Aug 2, 2011
Country EPO
Application number 06811315
Gazette No. 1988094
Gazette No. 1988094
Date of filing Oct 5, 2006
Gazette Date Nov 5, 2008
Gazette Date Jun 11, 2014
International application number JP2006319977
International publication number WO2007097065
Date of international filing Oct 5, 2006
Date of international publication Aug 30, 2007
Priority data
  • 2006JP319977 (Oct 5, 2006) WO
  • P2006-046950 (Feb 23, 2006) JP
Title Hapten compound and antibody
Abstract The present invention is a compound having a structure represented by the following formula (1): , and an antibody to BSH obtained by using the compound as a hapten and using a complex of the hapten and a high-molecular compound as an antigen.
By using the present invention, it becomes possible to provide a hapten compound for preparing an antibody recognizing BSH highly sensitively and highly selectively, an antibody to BSH, as well as a kit for measuring BSH and an immunological measuring method having high sensitivity and excellent in quantitative property using the antibody.
Scope of claims [claim1]
1. A compound having a structure represented by the following formula (1): (see diagramm)
[claim2]
2. A monoclonal antibody to mercaptoundecahydrododecaborate (BSH) obtained by using the compound as defined in claim 1 as a hapten and using a complex of the hapten and a high-molecular compound as an antigen.
[claim3]
3. A hybridoma producing a monoclonal antibody as defined in claim 2.
[claim4]
4. The hybridoma according to claim 3, wherein the hybridoma is BSF-2 (accession number FERM AP-20805).
[claim5]
5. A monoclonal antibody produced by the hybridoma of claim 4.
[claim6]
6. A kit for measuring mercaptoundecahydrododecaborate (BSH), comprising a monoclonal antibody as defined in claim 2 or 5.
[claim7]
7. A method of measuring mercaptoundecahydrododecaborate (BSH), comprising using a monoclonal antibody as defined in claim 2 or 5.
[claim8]
8. A method of measuring mercaptoundecahydrododecaborate (BSH), comprising using a kit as defined in claim 6.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • OSAKA PREFECTURE UNIVERSITY
  • STELLA CHEMIFA
  • Inventor
  • KIRIHATA MITSUNORI
  • ASANO TOMOYUKI
  • UEHARA KOHKI
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • C07F005/02D
  • C07K016/44
  • G01N033/53F
  • G01N033/84
  • G01N033/94
Specified countries Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
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