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Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide achieved

Foreign code F110005034
File No. A031-33US
Posted date Aug 18, 2011
Country United States of America
Application number 34338801
Gazette No. 20030149999
Gazette No. 7371921
Date of filing Jul 31, 2001
Gazette Date Aug 7, 2003
Gazette Date May 13, 2008
International application number JP2001006555
International publication number WO2002009508
Date of international filing Jul 31, 2001
Date of international publication Feb 7, 2002
Priority data
  • P2000-232451 (Jul 31, 2000) JP
  • 2001WO-JP06555 (Jul 31, 2001) WO
Title Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide achieved
Abstract (US7371921)
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model.
A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated.
With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.
Scope of claims [claim1]
1. A transgenic mouse whose genome comprises a homozygous disruption of the TLR-6 gene, said TLR-6 gene encoding a polypeptide that recognizes a MALP-2 mycoplasma-derived lipoprotein/lipopeptide, wherein macrophage cells isolated from the transgenic mouse are unresponsive to MALP-2.
[claim2]
2. A macrophage cell isolated from a transgenic mouse whose genome comprises a homozygous disruption of the TLR-6 gene, said TLR-6 gene encoding a polypeptide that recognizes a MALP-2 mycoplasma-derived lipoprotein/lipopeptide, wherein the macrophage cell is unresponsive to MALP-2.
  • Inventor, and Inventor/Applicant
  • AKIRA SHIZUO
  • TAKEUCHI OSAMU
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Host Defense Mechanism AREA
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