Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide
|Posted date||Aug 18, 2011|
|Country||United States of America|
|Date of filing||Jul 31, 2001|
|Gazette Date||Aug 7, 2003|
|Gazette Date||May 13, 2008|
|International application number||JP2001006555|
|International publication number||WO2002009508|
|Date of international filing||Jul 31, 2001|
|Date of international publication||Feb 7, 2002|
|Title||Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide|
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model.
A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated.
With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.
|Scope of claims||
1. A transgenic mouse whose genome comprises a homozygous disruption of the TLR-6 gene, said TLR-6 gene encoding a polypeptide that recognizes a MALP-2 mycoplasma-derived lipoprotein/lipopeptide, wherein macrophage cells isolated from the transgenic mouse are unresponsive to MALP-2.
2. A macrophage cell isolated from a transgenic mouse whose genome comprises a homozygous disruption of the TLR-6 gene, said TLR-6 gene encoding a polypeptide that recognizes a MALP-2 mycoplasma-derived lipoprotein/lipopeptide, wherein the macrophage cell is unresponsive to MALP-2.
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Host Defense Mechanism AREA|
Contact Information for " Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476