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Practical chiral zirconium catalyst

Foreign code F110005098
File No. A051-84US
Posted date Aug 19, 2011
Country United States of America
Application number 50730703
Gazette No. 20050164869
Gazette No. 7419933
Date of filing Mar 11, 2003
Gazette Date Jul 28, 2005
Gazette Date Sep 2, 2008
International application number JP2003002860
International publication number WO2003076072
Date of international filing Mar 11, 2003
Date of international publication Sep 18, 2003
Priority data
  • P2002-066122 (Mar 11, 2002) JP
  • 2003WO-JP02860 (Mar 11, 2003) WO
Title Practical chiral zirconium catalyst
Abstract (US7419933)
A practical chiral zirconium catalyst that can maintain its high catalytic activity even after long-term storage, which is stable in air and storable for a long period of time, and recoverable and reusable after reaction, is provided.
Scope of claims [claim1]
1. A practical chiral zirconium catalyst that is stable in air and storable for a long period of time, which comprises a chiral zirconium catalyst comprising, as its component, zirconium and an optically active binaphthol compound, and zeolite, wherein the chiral zirconium catalyst is fixed onto the zeolite, wherein the chiral zirconium catalyst is represented by the following formula (I):
wherein, X and Y are the same as or different from each other and represent a hydrogen atom, a halogen atom or a fluorinated hydrocarbon group, at least one of them being a halogen atom or a fluorinated hydrocarbon group;
and L represents N-methylimidazole or 1,2-dimethylimidazole.
[claim2]
2. The practical chiral zirconium catalyst of claim 1, wherein the fluorinated hydrocarbon group is a perfluoroalkyl group.
[claim3]
3. The practical chiral zirconium catalyst of claim 1, wherein the fluorinated hydrocarbon group is a perfluoroalkyl group of 1 to 6 carbon atoms.
[claim4]
4. The practical chiral zirconium catalyst of claim 1, wherein the zeolite is selected from the group consisting of Molecular Sieve 3A, Molecular Sieve 4A and Molecular Sieve 5A.
[claim5]
5. The practical chiral zirconium catalyst as claimed in claim 1, wherein the chiral zirconium catalyst is fixed on zeolite by electrostatic interaction.
[claim6]
6. A practical chiral zirconium catalyst of claim 1 obtained by the steps of: drying Molecular Sieve by heating under reduced pressure in an inert atmosphere;
mixing the Molecular Sieve with a zirconium alkoxide represented by the following formula (II):
Zr(OR)4 (II)
wherein R represents a hydrocarbon group that may contain a substituent;
and an (R)-BINOL represented by the following formula (III):
wherein X and Y may be the same as or different from each other, and represents a hydrogen atom, a halogen atom or a fluorinated hydrocarbon group, at least one of them being a halogen atom or a fluorinated hydrocarbon group.
[claim7]
7. The practical chiral zirconium catalyst of claim 6 obtained by further mixing a coordination compound with the zirconium alkoxide and the (R)-BINOL.
[claim8]
8. The practical chiral zirconium catalyst of claim 7, wherein the coordination compound is N-methylimidazole.
[claim9]
9. A method for an asymmetric Mannich reaction, comprising: reacting an imine and a silicon enolate in the presence of the practical chiral zirconium catalyst of claim 1.
[claim10]
10. A method for conducting an Aza Diels-Alder reaction which comprises employing the practical chiral zirconium catalyst of claim 1 as a catalyst for said reaction.
[claim11]
11. A method for conducting a Strecker reaction which comprises employing the practical chiral zirconium catalyst of claim 1 as a catalyst for said reaction.
[claim12]
12. A method for an asymmetric Mannich reaction, comprising: reacting an imine and a silicon enolate in the presence of the practical chiral zirconium catalyst of claim 6.
[claim13]
13. A method for conducting an Aza Diels-Alder reaction which comprises employing the practical chiral zirconium catalyst of claim 6 as a catalyst for said reaction.
[claim14]
14. A method or conducting a Strecker reaction which comprises employing the practical chiral zirconium catalyst of claim 6 as a catalyst for said reaction.
  • Inventor, and Inventor/Applicant
  • KOBAYASHI SHU
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Single Molecule and Atom Level Reactions AREA
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