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Cold spray mass spectrometric device 実績あり

外国特許コード F110005105
整理番号 A052-73US
掲載日 2011年8月23日
出願国 アメリカ合衆国
出願番号 34332903
公報番号 20030168586
公報番号 6977369
出願日 平成14年6月5日(2002.6.5)
公報発行日 平成15年9月11日(2003.9.11)
公報発行日 平成17年12月20日(2005.12.20)
国際出願番号 JP2002005540
国際公開番号 WO2002101788
国際出願日 平成14年6月5日(2002.6.5)
国際公開日 平成14年12月19日(2002.12.19)
優先権データ
  • 特願2001-174265 (2001.6.8) JP
  • 2002WO-JP05540 (2002.6.5) WO
発明の名称 (英語) Cold spray mass spectrometric device 実績あり
発明の概要(英語) (US6977369)
The instrument cold sprays a solution sample at a low temperature and desolvates the sample.
Under this condition, a mass analysis is performed.
The instrument comprises a needle pipe ( 8 ) through which the solution sample is passed, a sheath tube ( 24 ) formed coaxially with the needle pipe ( 8 ) and passing a temperature-controlled nebulizing gas therethrough, the above-described desolvation block ( 3 ), means for cooling the block ( 15 ), means for heating the block ( 4 ), and a temperature sensor ( 5 ) for detecting the temperature of the block ( 3 ).
The block ( 3 ) has a passage for charged liquid droplets of the solution sample cold sprayed from the tip of the needle pipe ( 8 ), and acts to remove the solvent from the charged liquid droplets flowing through the passage.
A coldspray mass spectrometer is offered which has a desolvation block whose temperature can be easily controlled.
In the instrument, condensation of water and electrical leakage are prevented for a long time.
The instrument can perform measurements stably and is easy to handle.
特許請求の範囲(英語) [claim1]
1. A coldspray mass spectrometer for performing a mass analysis by spraying a solution sample at a low temperature and desolvating the sample, said coldspray mass spectrometer comprising:
(a) a needle pipe through which the solution sample is passed;(b) a sheath tube which is formed coaxially with the needle pipe and through which a temperature-controlled nebulizing gas is passed;(c) a desolvation block having a passageway extending from a tip of the needle pipe, the passageway permitting passage of charged liquid droplets of the solution sample, the desolvation block acting to remove a solvent from the charged liquid droplets passing through the passageway;(d) cooling means for cooling the desolvation block;(e) heating means for heating the desolvation block;
and(f) a temperature sensor for detecting the temperature of the desolvation block;
wherein said desolvation block can be controlled to any desired temperature.
[claim2]
2. A coldspray mass spectrometer for performing a mass analysis by spraying a solution sample at a low temperature and desolvating the sample, said coldspray mass spectrometer comprising:
(a) a needle pipe through which the solution sample is passed;(b) a sheath tube which is formed coaxially with the needle pipe and through which a temperature-controlled nebulizing gas is passed;(c) a desolvation block having a passageway extending from a tip of the needle pipe, the passageway permitting passage of charged liquid droplets of the solution sample, the desolvation block acting to remove a solvent from the charged liquid droplets passing through the passageway;(d) cooling means for cooling the desolvation block;(e) heating means for heating the desolvation block;
and(f) a temperature sensor for detecting the temperature of the desolvation block;
wherein mode of operation of the mass spectrometer can be switched between coldspray ionization mode and normal electrospray ionization mode.
[claim3]
3. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein said desolvation block has a heating passage for desolvating said charged liquid droplets at a high temperature and a cooling passage for desolvating said charged liquid droplets at a low temperature, and wherein a passage for said charged liquid droplets can be selected between said heating passage and said cooling passage.
[claim4]
4. A coldspray mass spectrometer as set forth in claim 3, wherein anyone of said heating passage and said cooling passage is selected by moving said needle pipe.
[claim5]
5. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein a refrigerant passage is formed in said desolvation block, and wherein a refrigerant is passed through said refrigerant passage to thereby cool said desolvation block.
[claim6]
6. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein the temperature-controlled nebulizing gas supplied into the sheath tube and a refrigerant supplied into said means for cooling the desolvation block are supplied from a common refrigerator.
[claim7]
7. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein a space for accommodating an electrical circuit for controlling a coldspray ion source is formed separately from an ionization chamber in which said desolvation block is placed.
[claim8]
8. A coldspray mass spectrometer as set forth in claim 7, wherein a refrigerant already used to cool the desolvation block is discharged to the outside through said space.
[claim9]
9. A coldspray mass spectrometer as set forth in claim 7, further comprising a gas source for supplying a dry gas into said space.
  • 発明者/出願人(英語)
  • YAMAGUCHI KENTARO
  • KOBAYASHI TATSUJI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • JEOL
国際特許分類(IPC)
米国特許分類/主・副
  • B05B005/00A
  • H01J049/04L3
  • H01J049/04T
  • H01J049/16E
  • L05B005/025A
参考情報 (研究プロジェクト等) CREST Single Molecule and Atom Level Reactions AREA
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