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Cold spray mass spectrometric device achieved

Foreign code F110005105
File No. A052-73US
Posted date Aug 23, 2011
Country United States of America
Application number 34332903
Gazette No. 20030168586
Gazette No. 6977369
Date of filing Jun 5, 2002
Gazette Date Sep 11, 2003
Gazette Date Dec 20, 2005
International application number JP2002005540
International publication number WO2002101788
Date of international filing Jun 5, 2002
Date of international publication Dec 19, 2002
Priority data
  • P2001-174265 (Jun 8, 2001) JP
  • 2002WO-JP05540 (Jun 5, 2002) WO
Title Cold spray mass spectrometric device achieved
Abstract (US6977369)
The instrument cold sprays a solution sample at a low temperature and desolvates the sample.
Under this condition, a mass analysis is performed.
The instrument comprises a needle pipe ( 8 ) through which the solution sample is passed, a sheath tube ( 24 ) formed coaxially with the needle pipe ( 8 ) and passing a temperature-controlled nebulizing gas therethrough, the above-described desolvation block ( 3 ), means for cooling the block ( 15 ), means for heating the block ( 4 ), and a temperature sensor ( 5 ) for detecting the temperature of the block ( 3 ).
The block ( 3 ) has a passage for charged liquid droplets of the solution sample cold sprayed from the tip of the needle pipe ( 8 ), and acts to remove the solvent from the charged liquid droplets flowing through the passage.
A coldspray mass spectrometer is offered which has a desolvation block whose temperature can be easily controlled.
In the instrument, condensation of water and electrical leakage are prevented for a long time.
The instrument can perform measurements stably and is easy to handle.
Scope of claims [claim1]
1. A coldspray mass spectrometer for performing a mass analysis by spraying a solution sample at a low temperature and desolvating the sample, said coldspray mass spectrometer comprising:
(a) a needle pipe through which the solution sample is passed;(b) a sheath tube which is formed coaxially with the needle pipe and through which a temperature-controlled nebulizing gas is passed;(c) a desolvation block having a passageway extending from a tip of the needle pipe, the passageway permitting passage of charged liquid droplets of the solution sample, the desolvation block acting to remove a solvent from the charged liquid droplets passing through the passageway;(d) cooling means for cooling the desolvation block;(e) heating means for heating the desolvation block;
and(f) a temperature sensor for detecting the temperature of the desolvation block;
wherein said desolvation block can be controlled to any desired temperature.
[claim2]
2. A coldspray mass spectrometer for performing a mass analysis by spraying a solution sample at a low temperature and desolvating the sample, said coldspray mass spectrometer comprising:
(a) a needle pipe through which the solution sample is passed;(b) a sheath tube which is formed coaxially with the needle pipe and through which a temperature-controlled nebulizing gas is passed;(c) a desolvation block having a passageway extending from a tip of the needle pipe, the passageway permitting passage of charged liquid droplets of the solution sample, the desolvation block acting to remove a solvent from the charged liquid droplets passing through the passageway;(d) cooling means for cooling the desolvation block;(e) heating means for heating the desolvation block;
and(f) a temperature sensor for detecting the temperature of the desolvation block;
wherein mode of operation of the mass spectrometer can be switched between coldspray ionization mode and normal electrospray ionization mode.
[claim3]
3. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein said desolvation block has a heating passage for desolvating said charged liquid droplets at a high temperature and a cooling passage for desolvating said charged liquid droplets at a low temperature, and wherein a passage for said charged liquid droplets can be selected between said heating passage and said cooling passage.
[claim4]
4. A coldspray mass spectrometer as set forth in claim 3, wherein anyone of said heating passage and said cooling passage is selected by moving said needle pipe.
[claim5]
5. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein a refrigerant passage is formed in said desolvation block, and wherein a refrigerant is passed through said refrigerant passage to thereby cool said desolvation block.
[claim6]
6. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein the temperature-controlled nebulizing gas supplied into the sheath tube and a refrigerant supplied into said means for cooling the desolvation block are supplied from a common refrigerator.
[claim7]
7. A coldspray mass spectrometer as set forth in claim 1 or 2, wherein a space for accommodating an electrical circuit for controlling a coldspray ion source is formed separately from an ionization chamber in which said desolvation block is placed.
[claim8]
8. A coldspray mass spectrometer as set forth in claim 7, wherein a refrigerant already used to cool the desolvation block is discharged to the outside through said space.
[claim9]
9. A coldspray mass spectrometer as set forth in claim 7, further comprising a gas source for supplying a dry gas into said space.
  • Inventor, and Inventor/Applicant
  • YAMAGUCHI KENTARO
  • KOBAYASHI TATSUJI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • JEOL
IPC(International Patent Classification)
Reference ( R and D project ) CREST Single Molecule and Atom Level Reactions AREA
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