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Artificial pyramid

外国特許コード F110005164
整理番号 A121-08US
掲載日 2011年8月25日
出願国 アメリカ合衆国
出願番号 46801003
公報番号 20040082998
公報番号 6887272
出願日 平成14年2月20日(2002.2.20)
公報発行日 平成16年4月29日(2004.4.29)
公報発行日 平成17年5月3日(2005.5.3)
国際出願番号 JP2002001508
国際公開番号 WO2002065955
国際出願日 平成14年2月20日(2002.2.20)
国際公開日 平成14年8月29日(2002.8.29)
優先権データ
  • 特願2001-049493 (2001.2.23) JP
  • 2002WO-JP01508 (2002.2.20) WO
発明の名称 (英語) Artificial pyramid
発明の概要(英語) (US6887272)
Disclosed is an artificial vertebra having a bone-marrow regenerating function, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of the HAp particles along the Col fiber.
The HAp/Col composite body is formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto.
The present invention also provides a biodecomposable/bioabsorbable support for fixing an artificial vertebra, comprising a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding the injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction.
The plate has four corner regions each formed with a screw hole for fixing the plate to vertebral bodies.
特許請求の範囲(英語) [claim1]
1. An artificial vertebra system having a bone-marrow regenerating function and being transformable to an autologous bone, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have the weight ratio of HAp to Col ranging from 70:30 to 80:20 which is equivalent to that of a bone, and a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of said HAp particles along said Col fiber, said HAp/Col composite body being formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto, said aperture being perforated in the frontward/rearward direction and rightward/leftward direction relative to the front side of a human body in a configuration analogous to that of a Volkmann's canal, wherein a plural number of said apertures are arranged at even intervals.
[claim2]
2. The artificial vertebra as defined in claim 1, wherein said coprecipitate has a cross-linked surface.
[claim3]
3. The artificial vertebra as defined in claim 1, wherein said HAp/Col composite body is formed as a block having a horseshoe shape in a section orthogonal to the long axis thereof, wherein a portion of said block to be located frontward relative to the front side of a human body has a curved surface having an analogous shape to that of a vertebral body, and a portion of said block to be inserted into vertebral bodies has rectangular planer surfaces to provide an increased contact area with the vertebral bodies.
[claim4]
4. The artificial vertebra as defined in claim 1, wherein said aperture is perforated in the direction of the long axis of said HAp/Col composite body in a configuration analogous to that of a Haversian canal, wherein a plural number of said apertures are arranged at even intervals.
[claim5]
5. The artificial vertebra as defined in claim 1, wherein said HAp/Col composite body is adapted to receive a load in an early stage after implantation in cooperation with a polylactic acid plate, wherein said HAp/Col composite body has a function of being transformed into an autologous bone in such a manner that new bone (bone marrow) is initially formed in said perforated aperture and the transformation is then extended from said new bone region to the periphery thereof.
[claim6]
6. The artificial vertebra as defined in claim 1, which includes an osteogenic factor impregnated into said HAp/Col composite body.
[claim7]
7. An artificial vertebra assembly comprising in combination the artificial vertebra as defined in claim 1, and a biodecomposable/bioabsorbable support for fixing an artificial vertebra, including a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding said injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction, said plate having four corner regions each formed with a screw hole for fixing said plate to vertebral bodies.
[claim8]
8. An artificial vertebra assembly in combination the artificial vertebra, and the biodecomposable/bioabsorbable support as defined in claim 7, wherein said screw hole is perforated in the four corner regions of said plate in an oblique direction.
  • 発明者/出願人(英語)
  • SHINOMIYA KENICHI
  • ITOH SOICHIRO
  • TANAKA JUNZO
  • KIKUCHI MASANORI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE
国際特許分類(IPC)
米国特許分類/主・副
  • A61L027/46
  • A61L027/56
  • K61B017/80
  • K61F002/44
  • K61L430/38
参考情報 (研究プロジェクト等) CREST Creation and Functions of New Molecules and Molecular Assemblies AREA
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