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Artificial pyramid

Foreign code F110005164
File No. A121-08US
Posted date Aug 25, 2011
Country United States of America
Application number 46801003
Gazette No. 20040082998
Gazette No. 6887272
Date of filing Feb 20, 2002
Gazette Date Apr 29, 2004
Gazette Date May 3, 2005
International application number JP2002001508
International publication number WO2002065955
Date of international filing Feb 20, 2002
Date of international publication Aug 29, 2002
Priority data
  • P2001-049493 (Feb 23, 2001) JP
  • 2002WO-JP01508 (Feb 20, 2002) WO
Title Artificial pyramid
Abstract (US6887272)
Disclosed is an artificial vertebra having a bone-marrow regenerating function, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of the HAp particles along the Col fiber.
The HAp/Col composite body is formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto.
The present invention also provides a biodecomposable/bioabsorbable support for fixing an artificial vertebra, comprising a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding the injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction.
The plate has four corner regions each formed with a screw hole for fixing the plate to vertebral bodies.
Scope of claims [claim1]
1. An artificial vertebra system having a bone-marrow regenerating function and being transformable to an autologous bone, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have the weight ratio of HAp to Col ranging from 70:30 to 80:20 which is equivalent to that of a bone, and a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of said HAp particles along said Col fiber, said HAp/Col composite body being formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto, said aperture being perforated in the frontward/rearward direction and rightward/leftward direction relative to the front side of a human body in a configuration analogous to that of a Volkmann's canal, wherein a plural number of said apertures are arranged at even intervals.
[claim2]
2. The artificial vertebra as defined in claim 1, wherein said coprecipitate has a cross-linked surface.
[claim3]
3. The artificial vertebra as defined in claim 1, wherein said HAp/Col composite body is formed as a block having a horseshoe shape in a section orthogonal to the long axis thereof, wherein a portion of said block to be located frontward relative to the front side of a human body has a curved surface having an analogous shape to that of a vertebral body, and a portion of said block to be inserted into vertebral bodies has rectangular planer surfaces to provide an increased contact area with the vertebral bodies.
[claim4]
4. The artificial vertebra as defined in claim 1, wherein said aperture is perforated in the direction of the long axis of said HAp/Col composite body in a configuration analogous to that of a Haversian canal, wherein a plural number of said apertures are arranged at even intervals.
[claim5]
5. The artificial vertebra as defined in claim 1, wherein said HAp/Col composite body is adapted to receive a load in an early stage after implantation in cooperation with a polylactic acid plate, wherein said HAp/Col composite body has a function of being transformed into an autologous bone in such a manner that new bone (bone marrow) is initially formed in said perforated aperture and the transformation is then extended from said new bone region to the periphery thereof.
[claim6]
6. The artificial vertebra as defined in claim 1, which includes an osteogenic factor impregnated into said HAp/Col composite body.
[claim7]
7. An artificial vertebra assembly comprising in combination the artificial vertebra as defined in claim 1, and a biodecomposable/bioabsorbable support for fixing an artificial vertebra, including a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding said injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction, said plate having four corner regions each formed with a screw hole for fixing said plate to vertebral bodies.
[claim8]
8. An artificial vertebra assembly in combination the artificial vertebra, and the biodecomposable/bioabsorbable support as defined in claim 7, wherein said screw hole is perforated in the four corner regions of said plate in an oblique direction.
  • Inventor, and Inventor/Applicant
  • SHINOMIYA KENICHI
  • ITOH SOICHIRO
  • TANAKA JUNZO
  • KIKUCHI MASANORI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation and Functions of New Molecules and Molecular Assemblies AREA
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