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Process for producing porous composite materials

Foreign code F110005186
File No. A122-29US
Posted date Aug 25, 2011
Country United States of America
Application number 49230002
Gazette No. 20050004242
Gazette No. 7163965
Date of filing May 1, 2002
Gazette Date Jan 6, 2005
Gazette Date Jan 16, 2007
International application number JP2002004355
International publication number WO2003092759
Date of international filing May 1, 2002
Date of international publication Nov 13, 2003
Priority data
  • 2002WO-JP04355 (May 1, 2002) WO
Title Process for producing porous composite materials
Abstract (US7163965)
This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant.
The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability.
Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.
Scope of claims [claim1]
1. A process for producing porous and composite materials comprising steps of: cooling a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized, to gelate the gelatin;
freezing it;
and then lyophilizing the resultant.
[claim2]
2. A process for producing porous and composite materials comprising a step of introducing surface crosslinking between collagens to the porous and composite materials obtained by the process according to claim 1.
[claim3]
3. The process according to claim 2, wherein the step of introducing surface crosslinking is carried out by immersing the porous and composite materials in a solution containing a crosslinking agent.
[claim4]
4. The process according to any one of claims 1 to 3 comprising a step of adding a crosslinking agent to gelatinized collagen to introduce internal crosslinking between collagens.
[claim5]
5. The process according to any one of claims 1 to 3, wherein the calcium salt is hydroxyapatite.
[claim6]
6. A process for producing porous and composite materials comprising the following steps of:
1) gelatinizing at least a part of the collagen constituting a complex containing hydroxyapatite and collagen;
2) introducing internal crosslinking between collagens with the addition of a crosslinking agent to the complex;3) obtaining porous and composite materials by cooling the complex to gelate the gelatin, freezing it, and then lyophilizing the resultant;
and
4) introducing surface crosslinking between collagens by immersing the porous and composite materials in a solution containing a crosslinking agent.
[claim7]
7. The process according to claim 2 or 3, wherein internal and/or surface crosslinking between collagens is introduced using glutaraldehyde as a crosslinking agent.
[claim8]
8. The process according to any one of claims 1 to 3, wherein surface crosslinking between collagens is introduced by immersing the porous and composite materials in a solution containing a crosslinking agent comprising ethanol as a solvent.
[claim9]
9. The process according to any one of claims 1 to 3, wherein the resulting porous and composite materials have porosities of 80% or higher.
[claim10]
10. The process according to any one of claims 1 to 3 using a complex comprising the c-axis of hydroxyapatite being oriented along collagen fibers.
[claim11]
11. Porous and composite materials having porosities of 80% or higher, which are produced by the method according to any one of claims 1 to 3.
[claim12]
12. Implants of the porous and composite materials according to claim 11.
  • Inventor, and Inventor/Applicant
  • SOTOME SHINICHI
  • UEMURA TOSHIMASA
  • TANAKA JUNZO
  • KIKUCHI MASANORI
  • SHINOMIYA KENICHI
  • ITOH SOICHIRO
  • TATEISHI TETSUYA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation and Functions of New Molecules and Molecular Assemblies AREA
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