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Numb protein expression inhibitors by Musashi achieved

Foreign code F110005212
File No. A192-04US
Posted date Aug 26, 2011
Country United States of America
Application number 34331101
Gazette No. 20040054140
Gazette No. 7264793
Date of filing Nov 22, 2001
Gazette Date Mar 18, 2004
Gazette Date Sep 4, 2007
International application number JP2001010231
International publication number WO2002099102
Date of international filing Nov 22, 2001
Date of international publication Dec 12, 2002
Priority data
  • P2001-164412 (May 31, 2001) JP
  • 2001WO-JP10231 (Nov 22, 2001) WO
Title Numb protein expression inhibitors by Musashi achieved
Abstract (US7264793)
An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.
By the present invention, a new function of Musashi protein has been elucidated.
Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.
Scope of claims [claim1]
1. A method for potentiating neural stem cell proliferating activity, which comprises administering an effective amount of mammalian Musashi 1 protein to a mammalian subject by injection.
[claim2]
2. A method according to claim 1, wherein said injection is to the tissue or cells of said mammalian subject.
[claim3]
3. The method of claim 1, wherein said mammalian Musashi 1 protein is isolated from cells in which they are naturally expressed.
[claim4]
4. The method of claim 1, wherein said mammalian Musashi 1 protein is prepared by DNA recombination technology comprising transfected cells with an expression vector containing the cloned gene encoding for said mammalian Musashi 1 protein.
[claim5]
5. The method of claim 1, wherein said mammalian Musashi 1 protein is a mouse Musashi 1 protein.
[claim6]
6. The method of claim 1, wherein said mammalian Musashi 1 protein is isolated from mammalian CNS stem cells.
[claim7]
7. The method of claim 1, wherein said effective amount ranges from 0.1 mu g to 10 mg per day in terms of the weight of the Musashi 1 protein.
[claim8]
8. The method of claim 1, wherein said neural stem cell proliferation is by inhibiting expression of Numb protein .
[claim9]
9. The method of claim 1, wherein said neural stem cell proliferation is by potentiating Notch signaling.
  • Inventor, and Inventor/Applicant
  • IMAI TAKAO
  • TOKUNAGA AKINORI
  • YOSHIDA TETSU
  • MIKOSHIBA KATSUHIKO
  • NAKAFUKU MASATO
  • OKANO HIDEYUKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Development, Differentiation, and Regeneration in Biological Systems AREA
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