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Method of constructing spinal injury model monkey and utilization thereof meetings achieved

Foreign code F110005213
File No. A192-13US
Posted date Aug 26, 2011
Country United States of America
Application number 49699302
Gazette No. 20050186545
Gazette No. 7753054
Date of filing Nov 26, 2002
Gazette Date Aug 25, 2005
Gazette Date Jul 13, 2010
International application number JP2002012308
International publication number WO2003045137
Date of international filing Nov 26, 2002
Date of international publication Jun 5, 2003
Priority data
  • P2001-364563 (Nov 29, 2001) JP
  • 2002WO-JP12308 (Nov 26, 2002) WO
Title Method of constructing spinal injury model monkey and utilization thereof meetings achieved
Abstract (US7753054)
A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.
According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury.
This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury.
Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
Scope of claims [claim1]
1. A method for creating a monkey model of cervical spinal cord injury, comprising exposing the dura mater of the cervical cord of a monkey and applying a load onto the exposed dura mater of the cervical cord region, wherein the load weighs 15 to 25 g and is applied by being caused to fall from 20 to 60 mm above the dura mater, wherein the monkey model exhibits a protracted disorder in motor function compared to a monkey to which the load has not been applied.
[claim2]
2. The method according to claim 1, wherein the monkey in which spinal cord injury has been created has a motor function disorder which is comparable to that of human spinal cord injury.
[claim3]
3. The method according to claim 1, wherein said dura mater is exposed by excising any one of the C3 to C7 cervical vertebrae.
[claim4]
4. The method according to claim 1, wherein the protracted disorder of motor function is at least one member selected from the group consisting of limb movement, turning movement, seated posture, standing, jumping, extension of forelimbs, reaching with forelimb, grasping an object with forelimb, climbing, holding with limb, and combinations thereof.
  • Inventor, and Inventor/Applicant
  • OKANO HIDEYUKI
  • TOYAMA YOSHIAKI
  • NAKAMURA MASAYA
  • NOMURA TATSUJI
  • TANIOKA YOSHIKUNI
  • ANDO KIYOSHI
  • KANEMURA YONEHIRO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • KEIO UNIVERSITY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Development, Differentiation, and Regeneration in Biological Systems AREA
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