Method of determining absolute configuration of chiral compound
| Foreign code | F110005276 |
|---|---|
| File No. | E04703US |
| Posted date | Aug 29, 2011 |
| Country | United States of America |
| Application number | 14865200 |
| Gazette No. | 20030008406 |
| Gazette No. | 7354771 |
| Date of filing | Dec 4, 2000 |
| Gazette Date | Jan 9, 2003 |
| Gazette Date | Apr 8, 2008 |
| International application number | JP2000008559 |
| International publication number | WO2001040774 |
| Date of international filing | Dec 4, 2000 |
| Date of international publication | Jun 7, 2001 |
| Priority data |
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| Title | Method of determining absolute configuration of chiral compound |
| Abstract |
(US7354771) The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulkier than ethyl at at least one of the second peripheral carbon atoms from the carbon atom at the carbon chain crosslink site, and (ii) analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon based on the sign of the Cotton effect. The chiral compound has an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group. |
| Scope of claims |
[claim1] 1. A method for determining the absolute configuration of a chiral compound which comprises: coordinating the chiral compound to a metalloporphyrin represented by the following formula (I): {mu {{5,5'- (ethane-1, 2-diyl) bis [2, 3, 7, 8, 12, 13, 17, 18-octaethyl-21H, 23H-porphyrinato](4-)}-kappa N21, -kappa N22, -kappa N23, -kappa N24, -kappa N21', -kappa N22', -kappa N23', -kappa N24', }}dizinc, the chiral compound having an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group; and analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon of the chiral compound based on the sign of the Cotton effect, wherein when the first Cotton effect is positive, the absolute configuration of the chiral compound is (S), and when the first Cotton effect is negative, the absolute configuration of the chiral compound is (R). [claim2] 2. The method according to claim 1 wherein the chiral compound is 1) a primary amine, 2) a secondary amine, 3) a primary diamine, 4) a secondary diamine, 5) a monoalcohal, or 6) an aminoalcohol. |
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| IPC(International Patent Classification) | |
| Reference ( R and D project ) | ERATO INOUE Photo-chirogenesis AREA |
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