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METHOD OF DIAGNOSING ACUTE RENAL FAILURE meetings

Foreign code F110005355
File No. S2009-0807-C0
Posted date Sep 2, 2011
Country WIPO
International application number 2010JP058809
International publication number WO 2010/150613
Date of international filing May 25, 2010
Date of international publication Dec 29, 2010
Priority data
  • P2009-152448 (Jun 26, 2009) JP
Title METHOD OF DIAGNOSING ACUTE RENAL FAILURE meetings
Abstract Provided is a noninvasive, high-sensitivity, novel diagnosis method for acute renal failure. More specifically, provided is an acute renal failure diagnosis method which includes a step for measuring the amount of aquaporin-2 in urine of a test subject. Typically speaking, in the aforementioned method, if the amount of aquaporin-2 in urine of a test subject is significantly smaller than the amount of aquaporin-2 in urine of a control subject, then it is determined that the test subject contracted acute renal failure or is more seriously affected by acute renal failure than is the control subject. The aforementioned method is also related to an acute renal failure diagnosis reagent containing an antibody capable of specifically combining with aquaporin-2, as well as to an acute renal failure diagnosis kit.
Scope of claims (In Japanese)
【請求項1】 被験体の尿中のアクアポリン2の量を測定するステップを含む、急性腎不全の診断方法。

【請求項2】 以下のステップ:
 被験体の尿中のアクアポリン2の量を測定するステップ、及び
 被験体の尿中のアクアポリン2の量を、対照の尿中のアクアポリン2の量と比較するステップ
を含み、被験体の尿中のアクアポリン2の量が、対照の尿中のアクアポリン2の量と比較して有意に少ないときに、被験体が急性腎不全に罹患している、又は対照と比較してより重度の急性腎不全であることが示される、請求項1に記載の方法。

【請求項3】 アクアポリン2の量の測定に用いる尿サンプルが、尿から得られたエキソゾーム画分である、請求項1又は2に記載の方法。

【請求項4】 被験体がヒトである、請求項1~3のいずれか1項に記載の方法。

【請求項5】 急性腎不全が薬剤により引き起こされたものである、請求項1~4のいずれか1項に記載の方法。

【請求項6】 アクアポリン2の測定が、アクアポリン2に特異的に結合する抗体を用いた免疫学的測定法により行われる、請求項1~5のいずれか1項に記載の方法。

【請求項7】 アクアポリン2に特異的に結合し得る抗体を含有する、急性腎不全の診断薬。

【請求項8】 アクアポリン2に特異的に結合し得る抗体を含有する、急性腎不全の診断用キット。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • UNIVERSITY OF MIYAZAKI
  • Inventor
  • IKEDA Masahiro
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN(UTILITY MODEL),HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TH(PETTY PATENT),TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AL,AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LR(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)

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