Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome
| Foreign code | F110005400 |
|---|---|
| File No. | K02303WO |
| Posted date | Sep 5, 2011 |
| Country | United States of America |
| Application number | 73486408 |
| Gazette No. | 20110027187 |
| Gazette No. | 8858915 |
| Date of filing | Nov 21, 2008 |
| Gazette Date | Feb 3, 2011 |
| Gazette Date | Oct 14, 2014 |
| International application number | JP2008071212 |
| International publication number | WO2009069546 |
| Date of international filing | Nov 21, 2008 |
| Date of international publication | Jun 4, 2009 |
| Priority data |
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| Title | Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome |
| Abstract |
(US8858915) The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1. |
| Scope of claims |
[claim1] 1. A screening method for a therapeutic drug for metabolic syndrome, comprising: a step of bringing into contact a test substance and a polypeptide having the amino acid sequence identified as SEQ ID NO:2, and which binds to calcitonin receptor-like receptor (CRLR); and a step of detecting binding between the polypeptide and the test substance. |
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| IPC(International Patent Classification) |
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| Reference ( R and D project ) | PRESTO Metabolism and Cellular Function AREA |
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