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Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome

Foreign code F110005400
File No. K02303WO
Posted date Sep 5, 2011
Country United States of America
Application number 73486408
Gazette No. 20110027187
Gazette No. 8858915
Date of filing Nov 21, 2008
Gazette Date Feb 3, 2011
Gazette Date Oct 14, 2014
International application number JP2008071212
International publication number WO2009069546
Date of international filing Nov 21, 2008
Date of international publication Jun 4, 2009
Priority data
  • P2007-305122 (Nov 26, 2007) JP
  • 2008WO-JP71212 (Nov 21, 2008) WO
Title Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome
Abstract (US8858915)
The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others.
The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.
Scope of claims [claim1]
1. A screening method for a therapeutic drug for metabolic syndrome, comprising: a step of bringing into contact a test substance and a polypeptide having the amino acid sequence identified as SEQ ID NO:2, and which binds to calcitonin receptor-like receptor (CRLR); and
a step of detecting binding between the polypeptide and the test substance.
  • Inventor, and Inventor/Applicant
  • SHINDO TAKAYUKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) PRESTO Metabolism and Cellular Function AREA
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