Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof
| 外国特許コード | F110005476 |
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| 整理番号 | K05331WO |
| 掲載日 | 2011年9月6日 |
| 出願国 | アメリカ合衆国 |
| 出願番号 | 81490105 |
| 公報番号 | 20090023003 |
| 公報番号 | 8449979 |
| 出願日 | 平成17年12月12日(2005.12.12) |
| 公報発行日 | 平成21年1月22日(2009.1.22) |
| 公報発行日 | 平成25年5月28日(2013.5.28) |
| 国際出願番号 | JP2005023196 |
| 国際公開番号 | WO2006080157 |
| 国際出願日 | 平成17年12月12日(2005.12.12) |
| 国際公開日 | 平成18年8月3日(2006.8.3) |
| 優先権データ |
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| 発明の名称 （英語） | Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof |
| 発明の概要（英語） |
(US8449979) Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane. Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle. By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion. In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle. |
| 特許請求の範囲（英語） |
[claim1] 1. A bilayer membrane vesicle, comprising molecular aggregates containing: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane; and (d) a tertiary amine compound represented by the following formula II: wherein one or two of R2, R3, and R4 is a methyl group, and the remaining R2R3 and R4 is each independently -- CH2COOCnH2n+1 or -- CnH2n+1, or -- C6H4-p-CnH2n+1, where n is an integer of 6 to 20, and -- CnH2n+1 is linear. [claim2] 2. The bilayer membrane vesicle of claim 1, wherein the (b) alcohol or amine compound is a dihydric alcohol represented by the following formula I: R1 -- NH -- CH2 -- CH(OH) -- CH2OH (I) wherein R1 is an alkyl group having 6 to 20 carbon atoms, an alkenyl group having 6 to 20 carbon atoms, or an alkynyl group having 6 to 20 carbon atoms. [claim3] 3. The bilayer membrane vesicle of claim 1, wherein the mole ratio of the (a) fatty acid salt and the (b) alcohol or amine compound is 1:1. [claim4] 4. The bilayer membrane vesicle of claim 1, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1. [claim5] 5. The bilayer membrane vesicle of claim 1, wherein the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is a phospholipid. [claim6] 6. The bilayer membrane vesicle of claim 2, wherein the mole ratio of the (a) fatty acid salt and the (b) alcohol or amine compound is 1:1. [claim7] 7. The bilayer membrane vesicle of claim 2, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1. [claim8] 8. The bilayer membrane vesicle of claim 3, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1. [claim9] 9. The bilayer membrane vesicle of claim 2, wherein the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is a phospholipid. |
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| 国際特許分類(IPC) |
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| 参考情報 （研究プロジェクト等） | PRESTO Conversion and Control by Advanced Chemistry AREA |
日本語項目の表示
| 発明の名称 | 脱水縮合反応により相転移を生じ得る分子集合体およびその相転移方法 |
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