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Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof

外国特許コード F110005476
整理番号 K05331WO
掲載日 2011年9月6日
出願国 アメリカ合衆国
出願番号 81490105
公報番号 20090023003
公報番号 8449979
出願日 平成17年12月12日(2005.12.12)
公報発行日 平成21年1月22日(2009.1.22)
公報発行日 平成25年5月28日(2013.5.28)
国際出願番号 JP2005023196
国際公開番号 WO2006080157
国際出願日 平成17年12月12日(2005.12.12)
国際公開日 平成18年8月3日(2006.8.3)
優先権データ
  • 特願2005-021241 (2005.1.28) JP
  • 2005WO-JP23196 (2005.12.12) WO
発明の名称 （英語） Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof
発明の概要（英語） (US8449979)
Provided is a bilayer membrane vesicle capable of undergoing a phase transition.
The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane.
Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane.
Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle.
By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion.
In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle.
特許請求の範囲（英語） [claim1]
1. A bilayer membrane vesicle, comprising molecular aggregates containing: (a) a fatty acid salt having 6 to 20 carbon atoms;
(b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms;
(c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane; and
(d) a tertiary amine compound represented by the following formula II:

wherein one or two of R2, R3, and R4 is a methyl group, and the remaining R2R3 and R4 is each independently -- CH2COOCnH2n+1 or -- CnH2n+1, or -- C6H4-p-CnH2n+1, where n is an integer of 6 to 20, and -- CnH2n+1 is linear.
[claim2]
2. The bilayer membrane vesicle of claim 1, wherein the (b) alcohol or amine compound is a dihydric alcohol represented by the following formula I:
R1 -- NH -- CH2 -- CH(OH) -- CH2OH (I)
wherein R1 is an alkyl group having 6 to 20 carbon atoms, an alkenyl group having 6 to 20 carbon atoms, or an alkynyl group having 6 to 20 carbon atoms.
[claim3]
3. The bilayer membrane vesicle of claim 1, wherein the mole ratio of the (a) fatty acid salt and the (b) alcohol or amine compound is 1:1.
[claim4]
4. The bilayer membrane vesicle of claim 1, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1.
[claim5]
5. The bilayer membrane vesicle of claim 1, wherein the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is a phospholipid.
[claim6]
6. The bilayer membrane vesicle of claim 2, wherein the mole ratio of the (a) fatty acid salt and the (b) alcohol or amine compound is 1:1.
[claim7]
7. The bilayer membrane vesicle of claim 2, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1.
[claim8]
8. The bilayer membrane vesicle of claim 3, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1.
[claim9]
9. The bilayer membrane vesicle of claim 2, wherein the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is a phospholipid.
  • 発明者/出願人（英語）
  • KUNISHIMA MUNETAKA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 （研究プロジェクト等） PRESTO Conversion and Control by Advanced Chemistry AREA

日本語項目の表示

発明の名称 脱水縮合反応により相転移を生じ得る分子集合体およびその相転移方法
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  • 国立研究開発法人科学技術振興機構（ＪＳＴ） 知的財産マネジメント推進部
  • URL: http://www.jst.go.jp/chizai/
  • E-mail: e-mail address
  • Address: 〒102-8666 東京都千代田区四番町5-3
  • TEL: 03-5214-8293
  • FAX: 03-5214-8476

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『 Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof 』に関するお問合せ


  • 国立研究開発法人科学技術振興機構（ＪＳＴ） 知的財産マネジメント推進部
  • URL: http://www.jst.go.jp/chizai/
  • E-mail: e-mail address
  • Address: 〒102-8666 東京都千代田区四番町5-3
  • TEL: 03-5214-8293
  • FAX: 03-5214-8476

お問合せ

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関連情報

国内特許
公報 20090023003(PDF,793KB) PDF
公報 8449979(PDF,540KB) PDF
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