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Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof

Foreign code F110005476
File No. K05331WO
Posted date Sep 6, 2011
Country United States of America
Application number 81490105
Gazette No. 20090023003
Gazette No. 8449979
Date of filing Dec 12, 2005
Gazette Date Jan 22, 2009
Gazette Date May 28, 2013
International application number JP2005023196
International publication number WO2006080157
Date of international filing Dec 12, 2005
Date of international publication Aug 3, 2006
Priority data
  • P2005-021241 (Jan 28, 2005) JP
  • 2005WO-JP23196 (Dec 12, 2005) WO
Title Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof
Abstract (US8449979)
Provided is a bilayer membrane vesicle capable of undergoing a phase transition.
The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane.
Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane.
Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle.
By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion.
In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle.
Scope of claims [claim1]
1. A bilayer membrane vesicle, comprising molecular aggregates containing: (a) a fatty acid salt having 6 to 20 carbon atoms;
(b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms;
(c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane; and
(d) a tertiary amine compound represented by the following formula II:

wherein one or two of R2, R3, and R4 is a methyl group, and the remaining R2R3 and R4 is each independently -- CH2COOCnH2n+1 or -- CnH2n+1, or -- C6H4-p-CnH2n+1, where n is an integer of 6 to 20, and -- CnH2n+1 is linear.
[claim2]
2. The bilayer membrane vesicle of claim 1, wherein the (b) alcohol or amine compound is a dihydric alcohol represented by the following formula I:
R1 -- NH -- CH2 -- CH(OH) -- CH2OH (I)
wherein R1 is an alkyl group having 6 to 20 carbon atoms, an alkenyl group having 6 to 20 carbon atoms, or an alkynyl group having 6 to 20 carbon atoms.
[claim3]
3. The bilayer membrane vesicle of claim 1, wherein the mole ratio of the (a) fatty acid salt and the (b) alcohol or amine compound is 1:1.
[claim4]
4. The bilayer membrane vesicle of claim 1, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1.
[claim5]
5. The bilayer membrane vesicle of claim 1, wherein the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is a phospholipid.
[claim6]
6. The bilayer membrane vesicle of claim 2, wherein the mole ratio of the (a) fatty acid salt and the (b) alcohol or amine compound is 1:1.
[claim7]
7. The bilayer membrane vesicle of claim 2, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1.
[claim8]
8. The bilayer membrane vesicle of claim 3, wherein the mole ratio of the (a) fatty acid salt, the (b) alcohol or amine compound, and the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is 1:1:1.
[claim9]
9. The bilayer membrane vesicle of claim 2, wherein the (c) artificial synthetic lipid or phospholipid capable of forming a bilayer membrane is a phospholipid.
  • Inventor, and Inventor/Applicant
  • KUNISHIMA MUNETAKA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) PRESTO Conversion and Control by Advanced Chemistry AREA
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