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Peptides capable of binding to titanium silver silicone

外国特許コード F110005518
整理番号 N051-01WO
掲載日 2011年9月7日
出願国 アメリカ合衆国
出願番号 56653504
公報番号 20070112174
公報番号 7498403
出願日 平成16年7月30日(2004.7.30)
公報発行日 平成19年5月17日(2007.5.17)
公報発行日 平成21年3月3日(2009.3.3)
国際出願番号 JP2004011319
国際公開番号 WO2005010031
国際出願日 平成16年7月30日(2004.7.30)
国際公開日 平成17年2月3日(2005.2.3)
優先権データ
  • 特願2003-282509 (2003.7.30) JP
  • 2004WO-JP11319 (2004.7.30) WO
発明の名称 (英語) Peptides capable of binding to titanium silver silicone
発明の概要(英語) (US7498403)
The present invention provides a peptide sequence, a phage, an artificial protein or a chimeric molecule having a binding ability to titanium, silver, silicon, necessary to confer higher capacity of titanium, silver, silicon material with the use of soft matters, or to provide a complex of a peptide, a phage, an artificial protein or a chimeric molecule, and titanium, having the peptide sequence and functional peptide sequence.
By bringing into contact a population of phage wherein said phage of said population collectively express a library of different peptide sequence, recovering titanium bound to phage particles via peptide sequence by centrifugation, proliferating the obtained phage particles in bacteria, and repeating panning operation and concentrating titanium binding phage clones.
Among the phage clones, peptide RKLPDAPGMHTW (SEQ ID NO: 3) and the like is identified.
As for a peptide having a binding ability to titanium, silver, silicon, RKLPDA (SEQ ID NO: 1) or RALPDA (SEQ ID NO: 2) can be exemplified.
特許請求の範囲(英語) [claim1]
1. A titanium binding peptide consisting of the amino acid sequence of SEQ ID NO: 1.
[claim2]
2. A titanium binding peptide consisting of the amino acid sequence of SEQ ID NO: 2.
[claim3]
3. A titanium binding peptide comprising the amino acid sequence of SEQ ID NO: 3.
[claim4]
4. A titanium binding peptide comprising any one of the amino acid sequences of SEQ ID NOs: 4 to 14.
[claim5]
5. A titanium binding peptide comprising the amino acid sequence of SEQ ID NO: 15.
[claim6]
6. A titanium binding peptide comprising any one of the amino acid sequences of SEQ ID NOs: 16 to 24.
[claim7]
7. A titanium binding peptide comprising any one of the amino acid sequences of SEQ ID NOs: 25 to 38.
[claim8]
8. The titanium binding peptide according to claim 1, being chemically modified.
[claim9]
9. The titanium binding peptide according to claim 1, wherein titanium is a metal titanium, a titanium alloy or a titanium dioxide.
[claim10]
10. A titanium-peptide complex, wherein the titanium binding peptide according to claim 1 is bound to titanium.
[claim11]
11. An artificial titanium binding protein comprising the titanium binding peptide according to claim 1 conjugated, with a functional protein, wherein the functional protein is ferritin.
[claim12]
12. A titanium-artificial protein complex, wherein the artificial protein according to claim 11 is bound to titanium.
[claim13]
13. A titanium binding chimeric protein comprising the titanium binding peptide according to claim 1 conjugated, with a labeled substance, a peptide tag, or a nonpeptide compound, wherein the nonpeptide compound is an antibiotic, a fluorescein, a rhodamine, polystyrene, polypropylene, polyethylene, a glass bead, a silicagel, a polysaccharide, a polysaccharide delivative, or a polyalkylene glycol.
[claim14]
14. A titanium-chimeric protein complex, wherein the chimeric protein according to claim 13 is bound to titanium.
[claim15]
15. A titanium binding phage expressing the titanium binding peptide according to claim 1 on the particle surface.
[claim16]
16. A titanium-phage complex, wherein the phage according to claim 15 is bound to titanium.
[claim17]
17. A silver binding peptide consisting of the amino acid sequence of SEQ ID NO: 1.
[claim18]
18. A silver binding peptide consisting of the amino acid sequence of SEQ ID NO: 2.
[claim19]
19. A silver binding peptide comprising the amino acid sequence of SEQ ID NO: 3.
[claim20]
20. The silver binding peptide according to claim 17, 18 or 19, being chemically modified.
[claim21]
21. A silver-peptide complex, wherein the silver binding peptide according to claim 17, 18 or 19 is bound to silver.
[claim22]
22. A silver binding artificial protein comprising the silver binding peptide according to claim 17, 18 or 19 conjugated with a functional protein, wherein the functional protein is ferritin.
[claim23]
23. A silver-artificial protein complex, wherein the artificial protein according to claim 22 is bound to silver.
[claim24]
24. A silver binding chimeric protein comprising the silver binding peptide according to claim 17, 18 or 19 conjugated with a labeled substance, a peptide tag, or a nonpeptide compound, wherein the nonpeptide compound is an antibiotic, a fluorescein, a rhodamine, polystyrene, polypropylene, polyethylene, a glass bead, a silicagel, a polysaccharide, a polysaccharide delivative, or a polyalkylene glycol.
[claim25]
25. A silver-chimeric protein complex, wherein the chimeric protein according to claim 24 is bound to silver.
[claim26]
26. A silver binding phage expressing the silver binding peptide according to claim 17, 18 or 19 on the particle surface.
[claim27]
27. A silver-phage complex, wherein the phage according to claim 26 is bound to silver.
[claim28]
28. A silicon binding peptide consisting of the amino acid sequence of SEQ ID NO: 1.
[claim29]
29. A silicon binding peptide consisting of the amino acid sequence of SEQ ID NO: 2.
[claim30]
30. A silicon binding peptide comprising the amino acid sequence of SEQ ID NO: 3.
[claim31]
31. The silicon binding peptide according to claim 28, 29 or 30, being chemically modified.
[claim32]
32. A silicon-peptide complex, wherein the silicon binding peptide according to claim 28, 29 or 30 is bound to silicon.
[claim33]
33. A silicon binding artificial protein comprising the silicon binding peptide according to claim 28, 29 or 30 conjugated with a functional protein, wherein the functional protein is ferritin.
[claim34]
34. A silicon-artificial protein complex, wherein the artificial protein according to claim 33 is bound to silicon.
[claim35]
35. A silicon binding chimeric protein comprising the silicon binding peptide according to claim 28, 29 or 30 conjugated, with a labeled substance, a peptide-tag, or a nonpeptide compound, wherein the nonpeptide compound is an antibiotic, a fluorescein, a rhodamine, polystyrene, polypropylene, polyethylene, a glass bead, a silicagel, a polysaccharide, a polysaccharide delivative, or a polyalkylene glycol.
[claim36]
36. A silicon-chimeric protein complex wherein the chimeric protein according to claim 35 is bound to silicon.
[claim37]
37. A silicon binding phage expressing the silicon binding peptide according to claim 28, 29 or 30 on the particle surface.
[claim38]
38. A silicon-phage complex, wherein the phage according to claim 37 is bound to silicon.
  • 発明者/出願人(英語)
  • SHIBA KIYOTAKA
  • SANO KENICHI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Creation of Novel Nano-material/System Synthesized by Self-organization for Medical Use AREA
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