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Biostimulation apparatus, gene control apparatus, and muscle-related disorder therapeutic apparatus

Foreign code F110005528
File No. N052-22WO
Posted date Sep 7, 2011
Country United States of America
Application number 67899808
Gazette No. 20100280580
Gazette No. 8317847
Date of filing Sep 18, 2008
Gazette Date Nov 4, 2010
Gazette Date Nov 27, 2012
International application number JP2008002577
International publication number WO2009037841
Date of international filing Sep 18, 2008
Date of international publication Mar 26, 2009
Priority data
  • P2007-242851 (Sep 19, 2007) JP
  • 2008WO-JP02577 (Sep 18, 2008) WO
Title Biostimulation apparatus, gene control apparatus, and muscle-related disorder therapeutic apparatus
Abstract (US8317847)
A biostimulation apparatus of the present invention includes a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam, wherein the ultra short pulsed laser beam is focused by the optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to stimulate an acupuncture point, and wherein the target portion is either the acupuncture point or its periphery.
Scope of claims [claim1]
1. A biostimulation apparatus comprising a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam; the ultra short pulsed laser beam being focused by said optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to stimulate an acupuncture point;
wherein the target portion is either the acupuncture point or its periphery;
wherein the acupuncture point is stimulated by physical impact caused by the irradiation with the ultra short pulsed laser beam;
and wherein a pulse duration of the ultra short pulsed laser beam is in a range from 1.0 * 10-10 sec to 1.0 * 10-15 sec and a transient light intensity of the ultra short pulsed laser beam is in a range from 5 * 105 W to 1 * 1018 W.
[claim2]
2. The biostimulation apparatus as set forth in claim 1, wherein continuity of a living tissue is not discontinued due to the irradiation with the ultra short pulsed laser beam.
[claim3]
3. The biostimulation apparatus as set forth in claim 1, wherein the ultra short pulsed laser beam is focused, in the target portion of the living subject, at a tissue under a surface of the living subject.
[claim4]
4. The biostimulation apparatus as set forth in claim 3, wherein the ultra short pulsed laser beam is focused, in the target portion of the living subject, at a depth in a range from 100 mu m to 1 cm from the surface of the living subject.
[claim5]
5. The biostimulation apparatus as set forth in claim 1, wherein a wavelength of the ultra short pulsed laser beam is in a range from 600 to 1200 nm.
[claim6]
6. The biostimulation apparatus as set forth in claim 1, wherein the target portion is situated either in a skin tissue or in a muscle tissue.
[claim7]
7. The biostimulation apparatus as set forth in claim 1 further comprising acupuncture point detection means for detecting an acupuncture point and control means for deciding the target portion based on information from the acupuncture point detection means.
[claim8]
8. The biostimulation apparatus as set forth in claim 1, wherein improvement in blood flow is accelerated by stimulating the acupuncture point.
[claim9]
9. A gene control apparatus comprising a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam; wherein the ultra short pulsed laser beam is focused by said optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to control an expression level of a particular gene;
wherein the expression level of the particular gene is controlled using physical impact caused by the irradiation with the ultra short pulsed laser beam;
and wherein a pulse duration of the ultra short pulsed laser beam is in a range from 1.0 * 10-10 sec to 1.0 * 1015 sec and a transient light intensity of the ultra short pulsed laser beam is in a range from 5 * 105 W to 1 * 1018 W.
[claim10]
10. The gene control apparatus as set forth in claim 9, wherein continuity of a living tissue is not discontinued due to the irradiation with the ultra short pulsed laser beam.
[claim11]
11. The gene control apparatus as set forth in claim 9, wherein the ultra short pulsed laser beam is focused, in the target portion of the living subject, at a tissue under a surface of the living subject.
[claim12]
12. The gene control apparatus as set forth in claim 11, wherein the ultra short pulsed laser beam is focused, in the target portion of the living subject, at a depth in a range from 100 mu m to 1 cm from the surface of the living subject.
[claim13]
13. The gene control apparatus as set forth in claim 9, wherein a wavelength of the ultra short pulsed laser beam is in a range from 600 to 1200 nm.
[claim14]
14. The gene control apparatus as set forth in claim 9, wherein the ultra short pulsed laser beam is focused, by the optical system, at a target portion in a muscle tissue of the living subject to cause the target portion to be irradiated with the laser beam to control the expression level of a myostatin gene in the muscle tissue.
[claim15]
15. The gene control apparatus as set forth in claim 14, wherein enforcement or restoration of the muscle tissue or both are accelerated by controlling the expression level of the myostatin gene.
[claim16]
16. A muscle related disorder therapeutic apparatus comprising a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam; wherein the ultra short pulsed laser beam is focused, by the optical system, at a target portion in a muscle tissue of a living subject to cause the target portion to be irradiated with the laser beam to treat a muscle related disorder;
wherein the muscle related disorder is treated using physical impact caused by the irradiation with the ultra short pulsed laser beam;
and wherein a pulse duration of the ultra short pulsed laser beam is in a range from 1.0 * 10-10 sec to 1.0 * 10-15 sec and a transient light intensity of the ultra short pulsed laser beam is in a range from 5 * 105 W to 1 * 1018 W.
[claim17]
17. The muscle related disorder therapeutic apparatus as set forth in claim 16, wherein continuity of a living tissue is not discontinued due to the irradiation with the ultra short pulsed laser beam.
[claim18]
18. The muscle related disorder therapeutic apparatus as set forth in claim 16, wherein the ultra short pulsed laser beam is focused, in the target portion of the living subject, at a tissue under a surface of the living subject.
[claim19]
19. The muscle related disorder therapeutic apparatus as set forth in claim 18, wherein the ultra short pulsed laser beam is focused, in the target portion of the living subject, at a depth in a range from 100 mu m to 1 cm from the surface of the living subject.
[claim20]
20. The muscle related disorder therapeutic apparatus as set forth in claim 16, wherein a wavelength of the ultra short pulsed laser beam is in a range from 600 to 1200 nm.
  • Inventor, and Inventor/Applicant
  • HOSOKAWA YOICHIRO
  • MASUHARA HIROSHI
  • OKANO KAZUNORI
  • TAKAOKA YUTAKA
  • OHTA MIKA
  • ITO AKIHIKO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • KOBE UNIVERSITY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation of Novel Nano-material/System Synthesized by Self-organization for Medical Use AREA
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