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Monoclonal antibody to CD166 and method for production thereof UPDATE

外国特許コード F110005622
整理番号 RX03P53WO
掲載日 2011年9月9日
出願国 アメリカ合衆国
出願番号 08567406
公報番号 20090269787
公報番号 8003762
出願日 平成18年11月28日(2006.11.28)
公報発行日 平成21年10月29日(2009.10.29)
公報発行日 平成23年8月23日(2011.8.23)
国際出願番号 JP2006323662
国際公開番号 WO2007063825
国際出願日 平成18年11月28日(2006.11.28)
国際公開日 平成19年6月7日(2007.6.7)
優先権データ
  • 特願2005-344779 (2005.11.29) JP
  • 2006WO-JP323662 (2006.11.28) WO
発明の名称 (英語) Monoclonal antibody to CD166 and method for production thereof UPDATE
発明の概要(英語) (US8003762)
CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface.
If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically.
However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166.
The antibody was prepared by immunizing mice with a purified avian CD166 protein.
The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.
特許請求の範囲(英語) [claim1]
1. A monoclonal antibody, which specifically binds to the amino acid sequence of SEQ ID NO: 1 of cell adhesion molecule CD166/ALCAM.
[claim2]
2. The monoclonal antibody according to claim 1, wherein the subclass of the monoclonal antibody is immunoglobulin G.
[claim3]
3. A hybridoma, which produces the monoclonal antibody of claim 1.
[claim4]
4. A method of producing a monoclonal antibody, comprising purifying antibodies obtained from a mouse immunized with the amino acid sequence of SEQ ID NO: 1 to obtain a monoclonal antibody.
[claim5]
5. A method of measuring the level of CD166 in a sample, comprising contacting the monoclonal antibody according to claim 1 with the sample to thereby measure the level of CD166.
  • 発明者/出願人(英語)
  • TSUKAMOTO YASUHIRO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • OSAKA PREFECTURE UNIVERSITY
国際特許分類(IPC)
米国特許分類/主・副
  • C07K016/28A
  • C07K016/30
  • G01N033/574V2
  • K61K039/505
  • M07K316/960
  • S01N333/705B
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