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Method of treating allergies using TGF-β1 and allergens

外国特許コード F110005742
整理番号 P05-028US-D1
掲載日 2011年9月13日
出願国 アメリカ合衆国
出願番号 63800109
公報番号 20100183681
公報番号 8187613
出願日 平成21年12月15日(2009.12.15)
公報発行日 平成22年7月22日(2010.7.22)
公報発行日 平成24年5月29日(2012.5.29)
優先権データ
  • 特願2005-252912 (2005.8.31) JP
  • 2006US-11363371 (2006.2.28) US
発明の名称 (英語) Method of treating allergies using TGF-β1 and allergens
発明の概要(英語) (US8187613)
The invention provides an allergy prevention method or treatment method, diets and oral drugs enabling prevention/treatment of allergic symptoms without trouble such as systemic adverse reaction, immune deficiency and the like caused by transdermal/intravenous administration of TGF-&bgr;.
The allergy prevention method or treatment method is to orally administer 100 μg/kg or more of transforming growth factor-beta (TGF-&bgr;) relative to a weight of an administration target body and thereby selectively suppress Th2 immune response, while with respect to the diets and oral drugs, the content is set to contain an effective amount of transforming growth factor-beta (TGF-&bgr;) therein.
特許請求の範囲(英語) [claim1]
1. An oral drug composition for treating food allergy for administration to a target body comprising at least one causal substance of allergy and a transforming growth factor-beta 1 (TGF-beta1), wherein the causal substance of allergy is at least one food allergen.
[claim2]
2. The oral drug composition according to claim 1, wherein the TGF-beta1 is a human TGF-beta1.
[claim3]
3. The oral drug composition according to claim 1, wherein the administration target body is a human.
[claim4]
4. The oral drug composition according to claim 1, wherein the administration target body is a mouse.
[claim5]
5. The oral drug composition according to claim 1 wherein the administration target body is a dog.
[claim6]
6. The oral drug composition according to claim 1, wherein the administration target body is a pet animal.
[claim7]
7. The oral drug composition according to claim 1, wherein the food allergen is selected from the group consisting of milk, egg, rice, buckwheat, seafood, wheat, bean, fruit and mixtures thereof.
  • 発明者/出願人(英語)
  • NAKAO ATSUHITO
  • UNIVERSITY OF YAMANASHI
国際特許分類(IPC)
米国特許分類/主・副
  • A61K009/00M18
  • A61K038/18E
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