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Method of treating allergies using TGF-β1 and allergens

Foreign code F110005743
File No. P05-028US-D2
Posted date Sep 13, 2011
Country United States of America
Application number 63801909
Gazette No. 20100183682
Gazette No. 8182822
Date of filing Dec 15, 2009
Gazette Date Jul 22, 2010
Gazette Date May 22, 2012
Priority data
  • P2005-252912 (Aug 31, 2005) JP
  • 2006US-11363371 (Feb 28, 2006) US
Title Method of treating allergies using TGF-β1 and allergens
Abstract (US8182822)
The invention provides an allergy prevention method or treatment method, diets and oral drugs enabling prevention/treatment of allergic symptoms without trouble such as systemic adverse reaction, immune deficiency and the like caused by transdermal/intravenous administration of TGF-&bgr;.
The allergy prevention method or treatment method is to orally administer 100 μg/kg or more of transforming growth factor-beta (TGF-&bgr;) relative to a weight of an administration target body and thereby selectively suppress Th2 immune response, while with respect to the diets and oral drugs, the content is set to contain an effective amount of transforming growth factor-beta (TGF-&bgr;) therein.
Scope of claims [claim1]
1. A diet for an administration target body comprising at least one causal substance of allergy and a transforming growth factor-beta 1 (TGF-beta1), wherein said causal substance of allergy is at least one food allergen.
[claim2]
2. The diet according to claim 1, wherein TGF-beta1 is a human TGF-beta1.
[claim3]
3. The diet according to claim 1, wherein the diet is selected from the group consisting of foods and dietary supplements.
[claim4]
4. The diet according to claim 1, wherein the administration target body is a human.
[claim5]
5. The diet according to claim 1, wherein the administration target body is a mouse.
[claim6]
6. The diet according to claim 1, wherein the administration target body is a dog.
[claim7]
7. The diet according to claim 1, wherein the administration target body is a pet animal.
[claim8]
8. The diet according to claim 1, wherein the food allergen is selected from the group consisting of at least one of milk, milk products, eggs, rice, buckwheat, noodles, beans, flour, fruits, and seafood.
  • Inventor, and Inventor/Applicant
  • NAKAO ATSUHITO
  • UNIVERSITY OF YAMANASHI
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • A61K009/00M18
  • A61K038/18E
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