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Cardioinhibitory/antihypertensive novel endogenous physiologically active peptide

外国特許コード F110005768
整理番号 Y0461WO
掲載日 2011年9月14日
出願国 アメリカ合衆国
出願番号 59947905
公報番号 20080267871
公報番号 7829526
出願日 平成17年4月1日(2005.4.1)
公報発行日 平成20年10月30日(2008.10.30)
公報発行日 平成22年11月9日(2010.11.9)
国際出願番号 JP2005006510
国際公開番号 WO2005095609
国際出願日 平成17年4月1日(2005.4.1)
国際公開日 平成17年10月13日(2005.10.13)
優先権データ
  • 特願2004-110463 (2004.4.2) JP
  • 2005WO-JP06510 (2005.4.1) WO
発明の名称 (英語) Cardioinhibitory/antihypertensive novel endogenous physiologically active peptide
発明の概要(英語) (US7829526)
The present invention is to provide a novel peptide having a potent hypotensive activity by inhibiting cardiac contractility, a DNA encoding the peptide, an antibody against the peptide, or a cardioinhibitory/hypotensive agent comprising the peptide as an active ingredient.
A search of a genetic data base revealed the presence of a peptide biosynthesized by a processing of unspliced product of TOR2A mRNA.
As a result of functional analysis, a peptide hormone exerting a potent bioactivity and expressed abundantly throughout human organs was found.
The peptide is hydrophobic with a molecular weight of 2664.02 consisting of 24 amino acids (AIFIFISNTGGKQINQVALEAWRS; SEQ ID NO.: 2) and shows a negative inotropism in rat hearts, as well as a marked systemic hypotensive activity.
特許請求の範囲(英語) [claim1]
1. An isolated peptide consisting of any one of the following amino acid sequence (A) to (D): (A) the amino acid sequence shown by SEQ ID NO: 2;
(B) the amino acid sequence shown by position 1 to 20 of SEQ ID NO: 2;
(C) the amino acid sequence shown by position 5 to 24 of SEQ ID NO: 2; and
(D) the amino acid sequence shown by position 2 to 13 of SEQ ID NO: 2.
[claim2]
2. A fusion peptide comprising the peptide according to claim 1 and a marker protein, a peptide tag or a combination thereof.
[claim3]
3. A method for screening a cardioinhibitory factor or hypotensive factor, comprising the steps of administering an effective amount of the peptide according to claim 1 and a test substance to a non-human test animal, measuring a level of cardioinhibitory activity or hypotensive activity, and estimating the test substance as a cardioinhibitory factor in case that cardioinhibitory activity is higher when administering said peptide and said test substance than when administering the same amount of said peptide only, or estimating the test substance as a hypotensive factor in case that hypotensive activity is higher when administering said peptide and said test substance than when administering the same amount of said peptide only.
[claim4]
4. A method for screening an inhibitor of cardioinhibitory activity or an inhibitor of hypotensive activity, comprising the steps of administering an effective amount of the peptide according to claim 1 and a test substance to a non-human test animal, measuring a level of cardioinhibitory or hypotensive activity, and estimating the test substance as an inhibitor of cardioinhibitory activity in case that cardioinhibitory activity is lower when administering said peptide and said test substance than when administering the same amount of said peptide only, or estimating the test substance as an inhibitor of hypotensive activity in case that hypotensive activity is lower when administering the same amount of said peptide and said test substance than when administering said peptide only.
[claim5]
5. A cardioinhibitory/hypotensive agent comprising the peptide according to claim 1 as an active ingredient.
  • 発明者/出願人(英語)
  • SHICHIRI MASAYOSHI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • C07K014/575
  • C07K016/26
  • C07K016/40
  • K61K038/00
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