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Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same

Foreign code F110005790
File No. AF12-02WO
Posted date Sep 20, 2011
Country Canada
Application number 2728960
Gazette No. 2728960
Gazette No. 2728960
Date of filing Jun 26, 2009
Gazette Date Dec 30, 2009
Gazette Date Apr 12, 2016
International application number JP2009061772
International publication number WO2009157561
Date of international filing Jun 26, 2009
Date of international publication Dec 30, 2009
Priority data
  • P2008-167823 (Jun 26, 2008) JP
  • 2009JP061772 (Jun 26, 2009) WO
Title Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same
Abstract The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor--specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.
The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • KATAOKA KAZUNORI
  • KAIDA SACHIKO
  • CABRAL HORACIO
  • KUMAGAI MICHIAKI
  • SEKINO MASAKI
IPC(International Patent Classification)
Reference ( R and D project ) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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