Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same
|Posted date||Sep 20, 2011|
|Date of filing||Jun 26, 2009|
|Gazette Date||Dec 30, 2009|
|Gazette Date||Apr 12, 2016|
|International application number||JP2009061772|
|International publication number||WO2009157561|
|Date of international filing||Jun 26, 2009|
|Date of international publication||Dec 30, 2009|
|Title||Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same|
The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor--specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.
The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA|
Contact Information for " Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
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