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WATER-SOLUBLE DRUG CARRIER AND PROCESS FOR PRODUCTION THEREOF

Foreign code F110005946
File No. QP100027-PC
Posted date Nov 28, 2011
Country WIPO
International application number 2010JP004021
International publication number WO 2011/004552
Date of international filing Jun 16, 2010
Date of international publication Jan 13, 2011
Title WATER-SOLUBLE DRUG CARRIER AND PROCESS FOR PRODUCTION THEREOF
Abstract Disclosed are: a drug delivery carrier which has no concern about the leakage of a drug therefrom, can control particle sizes thereof easily, is widely applicable even to drugs other than drugs that do not have high anionic properties, besides water-soluble drugs, can deliver water-soluble substances such as genes and proteins, and can be used as a non-viral gene vector; and a process for producing the drug delivery carrier. The drug delivery carrier is characterized in that a water-soluble drug are double-coated with two types of surfactants 1 and 2. The drug delivery carrier can be produced by a process comprising the steps of: 1) mixing an aqueous phase containing the water-soluble drug with an oily phase containing the surfactant 1 while agitating to form a W/O emulsion in which the aqueous phase containing the water-soluble drug is dispersed in the oily phase; 2) removing the inner aqueous phase from the W/O emulsion to form an S/O in which a complex of the water-soluble drug and the surfactant 1 is dispersed in the oily phase; 3) mixing the S/O with an aqueous phase containing the surfactant 2 while agitating to form an S/O/W emulsion in which the S/O is dispersed in the aqueous phase; and 4) removing the inner oily phase from the S/O/W emulsion to form an S/W in which a complex of the water-soluble drug, the surfactant 1 and the surfactant 2 is dispersed in the aqueous phase.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
  • Inventor
  • GOTO, Masahiro
  • KAMIYA, Noriho
  • TAHARA, Yoshiro
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN(UTILITY MODEL),HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TH(PETTY PATENT),TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AL,AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LR(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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