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Light-responsive artificial nucleotide having photo-crosslinking ability

外国特許コード F120006086
整理番号 S2008-0144
掲載日 2012年1月6日
出願国 アメリカ合衆国
出願番号 74332408
公報番号 20100274000
公報番号 8481714
出願日 平成20年11月19日(2008.11.19)
公報発行日 平成22年10月28日(2010.10.28)
公報発行日 平成25年7月9日(2013.7.9)
国際出願番号 JP2008003376
国際公開番号 WO2009066447
国際出願日 平成20年11月19日(2008.11.19)
国際公開日 平成21年5月28日(2009.5.28)
優先権データ
  • 特願2007-299914 (2007.11.19) JP
  • 2008WO-JP03376 (2008.11.19) WO
発明の名称 (英語) Light-responsive artificial nucleotide having photo-crosslinking ability
発明の概要(英語) (US8481714)
The present invention provides a photoreactive crosslinking agent that is capable of crosslinking a sequence which cannot be photo-crosslinked by psoralen, and is capable of photo-crosslinking using a light having a longer wavelength, as compared with psoralen.
The present invention also provides a compound having a group represented by formula (I) coupled with a group represented by formula (II).
特許請求の範囲(英語) [claim1]
1. An agent comprising: a compound represented by the following formula (V)
wherein, in the formula (V), Ra represents a cyano group, an amide group, a carboxyl group, a C2-C7 alkoxycarbonyl group, or hydrogen,
wherein, in the formula (V), R1 and R2 each independently represent a cyano group, an amide group, a carboxyl group, a C2-C7 alkoxycarbonyl group, or hydrogen, and
wherein, in the formula (V), Rb represents a sugar, a polysaccharide, a polyether, a polyol, a polypeptide chain, or a water-soluble synthetic polymer.
[claim2]
2. The agent according to claim 1, wherein Rb is represented by the following formula (III) or formula (IV):
[claim3]
3. The agent according to claim 1, wherein the compound is a nucleoside.
[claim4]
4. The agent according to claim 1, wherein the compound is a nucleotide.
[claim5]
5. The agent according to claim 1, wherein the compound is a nucleic acid.
[claim6]
6. The agent according to claim 1, wherein Rb is represented by the following formula (IX) or formula (X):
[claim7]
7. The agent according to claim 6, wherein the compound is represented by one of the following formulae:
[claim8]
8. A method of forming a crosslink, comprising: providing a compound and a nucleobase having a pyrimidine ring, and
irradiating the compound and the nucleobase with light,
wherein the compound is represented by the following formula (V):
wherein, in the formula (V), Ra represents a cyano group, an amide group, a carboxyl group, a C2-C7 alkoxycarbonyl group, or hydrogen,
wherein, in the formula (V), R1 and R2 each independently represent a cyano group, an amide group, a carboxyl group, a C2-C7 alkoxycarbonyl group, or hydrogen, and
wherein, in the formula (V), Rb represents a sugar, a polysaccharide, a polyether, a polyol, a polypeptide chain, or a water-soluble synthetic polymer.
[claim9]
9. The method of claim 8, wherein Rb is represented by the following formula (III) or formula (IV):
[claim10]
10. A method for producing a nucleic acid, comprising: synthesizing a nucleic acid using the compound of claim 6 as a synthesizing reagent.
[claim11]
11. A method for producing a nucleic acid, comprising: synthesizing a nucleic acid using the compound of claim 7 as a synthesizing reagent.
  • 発明者/出願人(英語)
  • FUJIMOTO KENZO
  • YOSHIMURA YOSHINAGA
  • TOBA SHINYA
  • NITTA YUKARI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • C07D209/86
  • C07D405/04
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