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Nanofunctional silica particles and manufacturing method thereof 実績あり

外国特許コード F120006087
整理番号 S2008-0148
掲載日 2012年1月6日
出願国 アメリカ合衆国
出願番号 73496808
公報番号 20100310872
公報番号 9265729
出願日 平成20年12月8日(2008.12.8)
公報発行日 平成22年12月9日(2010.12.9)
公報発行日 平成28年2月23日(2016.2.23)
国際出願番号 JP2008072285
国際公開番号 WO2009072657
国際出願日 平成20年12月8日(2008.12.8)
国際公開日 平成21年6月11日(2009.6.11)
優先権データ
  • 特願2007-316466 (2007.12.6) JP
  • 2008WO-JP72285 (2008.12.8) WO
発明の名称 (英語) Nanofunctional silica particles and manufacturing method thereof 実績あり
発明の概要(英語) (US9265729)
Provided are nanofunctional silica particles having excellent functionality and quality, and capable of being mass-produced at low costs.
According to the present invention, there are provided nanofunctional silica particles including a coating layer containing one or more silica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), and aminopropyl trimethoxysilane (APS); and functional particles in the coating layer, and being used in imaging, assay, diagnosis, treatment or the like, medicine or bioresearch.
特許請求の範囲(英語) [claim1]
1. Nanofunctional non-porous silica particles, comprising a shell made mainly of silica obtained from one or more organosilica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), aminopropyl trimethoxysilane (APS), and aminopropyl triethoxysilane (APES); and a core, in the shell, having a diameter of 2 to 200 nm and containing one or more species selected from the group consisting of a magnetic material, gold colloid, a quantum dot, gadolinium-containing particles, and an imaging functional material-containing liquid, wherein a thickness of the shell is more than 5 nm and less than 100 nm and wherein a functional compound chosen from fluorescent material or an imaging agent is held in the shell and in the core.
[claim2]
2. The nanofunctional non-porous silica particles according to claim 1, wherein the shell is made of two or more organosilica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), aminopropyl trimethoxysilane (APS), and aminopropyl triethoxysilane (APES).
[claim3]
3. The nanofunctional non-porous silica particles according to claim 1, wherein the thickness of the shell is more than 5 nm and less than 30 nm.
[claim4]
4. The nanofunctional non-porous silica particles according to claim 1, wherein a difference in surface potential between the shell and the functional compound itself is 3 mV or more.
[claim5]
5. The nanofunctional non-porous silica particles according to claim 1, wherein each of the nanofunctional non-porous silica particles have a particle diameter of 3 to 500 nm.
[claim6]
6. The nanofunctional non-porous silica particles according to claim 1, wherein a material having a cell damage activating function is held in the surface of the shell, and/or in the shell, and/or in the core.
[claim7]
7. The nanofunctional non-porous silica particles according to claim 6, wherein the material is irradiated with light to exhibit the cell damage activating function.
[claim8]
8. A method for manufacturing nanofunctional non-porous silica particles as recited in claim 1, comprising steps for: (a) preparing a mixed liquid of an organosilica compound, a functional material, and an aqueous ammonia solution; or preparing a mixed liquid of an organosilica compound, a functional material, a functional compound, and an aqueous ammonia solution, and
(b) allowing the organosilica compound and the aqueous ammonia solution to react with one another at a predetermined temperature, wherein
the organosilica compound is one or more selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TcPS), acryloxypropyl trimethoxysilane (ACPS) and aminopropyl trimethoxysilane (APS),
the functional material is one or more species selected from the group consisting of a magnetic material, gold colloid, a quantum dot, gadolinium-containing particles, and an imaging functional material-containing liquid, and wherein
the aqueous ammonia solution and conditions for the temperature in the steps (a) and (b) are adjusted to satisfy the following:
(i) the temperature is high temperature (in the temperature range of 80 to 100 deg. C.), and
(ii) the solution has high ammonia concentration (the solution gives a final concentration of 25% or more).
[claim9]
9. A method for manufacturing nanofunctional non-porous silica particles as recited in claim 1, comprising steps for: (a) preparing a mixed liquid of organosilica compounds, a functional material, and an aqueous ammonia solution; or preparing a mixed liquid of organosilica compounds, a functional material, a functional compound, and an aqueous ammonia solution, and
(b) allowing the organosilica compounds and the aqueous ammonia solution to react with each other at a predetermined temperature, wherein
the organosilica compounds are one or more selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TcPS), acryloxypropyl trimethoxysilane (ACPS) and aminopropyl trimethoxysilane (APS), and aminopropyl triethoxysilane (APES),
the functional material is one or more species selected from the group consisting of a magnetic material, gold colloid, a quantum dot, gadolinium-containing particles, and an imaging functional material-containing liquid, and wherein
the aqueous ammonia solution and conditions for the temperature in the steps (a) and (b) are adjusted to satisfy the following:
(i) the temperature is high temperature (in the temperature range of 80 to 100 deg. C.), and
(ii) the solution has a high ammonia concentration (the solution gives a final concentration of 25% or more).
  • 発明者/出願人(英語)
  • NAKAMURA MICHIHIRO
  • TOKUSHIMA UNIVERSITY
国際特許分類(IPC)
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