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Cancer cell migration and cancer cell invasion inhibitor

Foreign code F120006106
File No. S2008-0392
Posted date Jan 6, 2012
Country United States of America
Application number 93413309
Gazette No. 20110070163
Gazette No. 8674079
Date of filing Mar 19, 2009
Gazette Date Mar 24, 2011
Gazette Date Mar 18, 2014
International application number JP2009055479
International publication number WO2009119455
Date of international filing Mar 19, 2009
Date of international publication Oct 1, 2009
Priority data
  • P2008-083588 (Mar 27, 2008) JP
  • 2009WO-JP55479 (Mar 19, 2009) WO
Title Cancer cell migration and cancer cell invasion inhibitor
Abstract (US8674079)
Provided are an antibody which binds specifically PAR1 (protease activated receptor 1) or a fragment of the antibody which retains similar characteristics thereto; a composition containing the same for inhibiting the migration activity and invasion activity of cancer cells; and a medicinal composition for treating cancer and the like.
Scope of claims [claim1]
1. A monoclonal antibody produced by a hybridoma having an accession number of FERM BP-11105 assigned by International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, or a antigen-binding antibody fragment thereof.
[claim2]
2. The antibody according to claim 1, wherein the antibody is chimeric or humanized, or a antigen-binding antibody fragment thereof.
[claim3]
3. A composition for inhibiting migration activity and invasion activity of cancer cells, comprising the antibody of claim 1 or antigen-binding antibody fragment thereof.
[claim4]
4. A medicinal composition for treating cancers, comprising the antibody or antigen-binding antibody fragment thereof according to claim 1.
[claim5]
5. A method for treating cancers, which comprises administering an effective amount of a medicinal composition containing the antibody or antigen-binding antibody fragment according to claim 1 to a subject in need of such treatment.
[claim6]
6. A method for imaging tumor cells or a method for detecting a tumor in a sample, which comprises bringing the antibody or antigen-binding antibody fragment according to claim 1 into contact with a sample obtained from a subject to bind it to tumor cells in the sample.
[claim7]
7. An imaging agent for tumor cells, comprising the antibody or a antigen-binding antibody fragment thereof according to claim 1.
[claim8]
8. A method for diagnosing a tumor, which comprises administering the antibody or antigen-binding antibody fragment according to claim 1 to a subject to investigate the binding of the antibody or antigen-binding antibody fragment of the present invention to a tumor tissue in the body.
[claim9]
9. A method for preparing an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using a peptide comprising the amino acid sequence as shown in SEQ ID NO: 1.
[claim10]
10. A method for purifying an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using a peptide comprising the amino acid sequence as shown in SEQ ID NO: 1.
[claim11]
11. A method for preparing an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using the antigenic peptide comprising the amino acid sequence as shown in SEQ ID NO: 1 and a carrier protein.
[claim12]
12. A method for purifying an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using the antigenic peptide comprising the amino acid sequence as shown in SEQ ID NO: 1 and a carrier protein.
  • Inventor, and Inventor/Applicant
  • GONDA KOHSUKE
  • HIGUCHI HIDEO
  • OHUCHI NORIAKI
  • TAKEDA MOTOHIRO
  • TOHOKU UNIVERSITY
IPC(International Patent Classification)
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