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Method for detection of idiopathic interstitial pneumonia

外国特許コード F120006119
整理番号 S2008-0668
掲載日 2012年1月6日
出願国 アメリカ合衆国
出願番号 99576909
公報番号 20110086360
公報番号 8420310
出願日 平成21年6月3日(2009.6.3)
公報発行日 平成23年4月14日(2011.4.14)
公報発行日 平成25年4月16日(2013.4.16)
国際出願番号 JP2009060567
国際公開番号 WO2009148184
国際出願日 平成21年6月3日(2009.6.3)
国際公開日 平成21年12月10日(2009.12.10)
優先権データ
  • 特願2008-147822 (2008.6.5) JP
  • 2009WO-JP60567 (2009.6.3) WO
発明の名称 (英語) Method for detection of idiopathic interstitial pneumonia
発明の概要(英語) (US8420310)
The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample.
Thereby, a method for detecting idiopathic interstitial pneumonia using a marker is provided.
特許請求の範囲(英語) [claim1]
1. A method for detecting idiopathic interstitial pneumonia, which comprises: a) obtaining a biological sample from a subject suspected of having idiopathic interstitial pneumonia; and
b) measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample obtained from the subject suspected of having idiopathic interstitial pneumonia,
wherein the periostin gene is selected from the group consisting of polynucleotide sequences set forth in SEQ ID NOs: 1, 3 and 5, and wherein the periostin protein is selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 2, 4 and 6, and
wherein an elevated expression level of the periostin gene or an elevated amount of the periostin protein is indicative of idiopathic interstitial pneumonia,
wherein the subject is suspected of having idiopathic interstitial pneumonia by having tested positive for idiopathic interstitial pneumonia with at least one selected from the group consisting of the results of physical findings, serological examination results, respiratory function test results, the results of chest X-ray image findings, and the results of chest HRCT image findings.
[claim2]
2. The method according to claim 1, wherein the idiopathic interstitial pneumonia is idiopathic pulmonary fibrosis or nonspecific interstitial pneumonia.
[claim3]
3. The method according to claim 2, wherein the nonspecific interstitial pneumonia is fibrotic nonspecific interstitial pneumonia (fibrotic NSIP).
[claim4]
4. The method according to claim 1, wherein the measurement is carried out by an immunoassay.
[claim5]
5. The method according to claim 1, wherein the biological sample is lung tissues and/or blood.
[claim6]
6. The method according to claim 1, which comprises comparing (i) the expression level of a periostin gene or the amount of a periostin protein in a biological sample derived from a subject, with (ii) the expression level of a periostin gene or the amount of a periostin protein in a biological sample derived from a normal person.
[claim7]
7. The method according to claim 6, which comprises determining that the subject has or is suspected to have idiopathic interstitial pneumonia, when (i) the expression level of a periostin gene or the amount of a periostin protein in the biological sample derived from the subject is higher than (ii) the expression level of a periostin gene or the amount of a periostin protein in the biological sample derived from a normal person.
[claim8]
8. The method according to claim 1, wherein the periostin gene is the polynucleotide sequence set forth in SEQ ID NO: 1, and wherein the periostin protein is the amino acid sequence set forth in SEQ ID NO: 2.
  • 発明者/出願人(英語)
  • IZUHARA KENJI
  • OHTA SHOICHIRO
  • SHIRAISHI HIROSHI
  • AIZAWA HISAMICHI
  • HOSHINO TOMOAKI
  • OKAMOTO MASAKI
  • KURUME UNIVERSITY
  • SAGA UNIVERSITY
国際特許分類(IPC)
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