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NONHUMAN ANIMAL MODEL OF TYPE 2 DIABETES meetings

Foreign code F120006163
File No. 09055PC
Posted date Jan 30, 2012
Country WIPO
International application number 2010JP070006
International publication number WO 2011/058994
Date of international filing Nov 10, 2010
Date of international publication May 19, 2011
Priority data
  • P2009-258382 (Nov 11, 2009) JP
  • P2010-181161 (Aug 12, 2010) JP
Title NONHUMAN ANIMAL MODEL OF TYPE 2 DIABETES meetings
Abstract Provided is a novel nonhuman animal model of type 2 diabetes which spontaneously causes a pathology similar to nonobese type 2 diabetes common among Japanese people, wherein the function of the Cdkal1 gene is specifically suppressed on the chromosome of the pancreas .beta. cell. Specifically, the nonhuman animal model of type 2 diabetes may be prepared by mating: a nonhuman animal having a site-specific recombinase-recognition sequence on the 3'-untranslated region and the 5'-untranslated region of a predetermined region containing one or more exons in the Cdkal1 gene; and a nonhuman animal in which a site-specific recombinase gene which recognizes the aforementioned site-specific recombinase-recognition sequence, and can cutout the aforementioned predetermined region is inserted in a manner so as to be able to express on the downstream of the promoter of a gene that specifically expresses in the pancreas.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
  • Inventor
  • TOMIZAWA Kazuhito
  • WEI Fanyan
IPC(International Patent Classification)
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