Top > Search of International Patents > Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug

Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug achieved

Foreign code F120006245
File No. S2009-0108-N0
Posted date Feb 17, 2012
Country United States of America
Application number 200913130952
Gazette No. 20110230659
Gazette No. 9273050
Date of filing Nov 27, 2009
Gazette Date Sep 22, 2011
Gazette Date Mar 1, 2016
International application number JP2009070062
International publication number WO2010061931
Date of international filing Nov 27, 2009
Date of international publication Jun 3, 2010
Priority data
  • P2008-303239 (Nov 27, 2008) JP
  • 2009WO-JP70062 (Nov 27, 2009) WO
Title Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug achieved
Abstract (US9273050)
Provided is a compound having at least one selected from the group consisting of cell growth promoting activity, angiogenesis promoting activity, lumen formation promoting activity, cell migration promoting activity, and neurocyte growth promoting activity, which is a chemically stable low-molecular-weight substance that has high absorbability and can be supplied stably at a low cost because of its low molecular weight.
A cyclobutyl purine derivative, a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof according to the present invention is a cyclobutyl purine derivative represented by the following general formula (1), a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof.
Scope of claims [claim1]
1. A cyclobutyl purine derivative represented by the following formula (1), a tautomer or a stereoisomer thereof, or a salt thereof:

where: X1 is chlorine;
X2 is NH2;
X3 is a hydrogen atom; and
each of R1 and R2 is C2OH.
[claim2]
2. The cyclobutyl purine derivative according to claim 1, the tautomer or the stereoisomer thereof, or the salt thereof, which is 6-amino-2-chloro-9-[trans-trans-2,3-bis(hydroxymethyl)cyclobutyl]purine a tautomer or a stereoisomer thereof, or a salt, a solvate, or a hydrate thereof.
[claim3]
3. A promoting agent having at least one function selected from the group consisting of an angiogenesis-promoting function, a lumen formation-promoting function, and a neurocyte growth-promoting function, the promoting agent comprising: a cyclobutyl purine derivative that is represented by following formula (1'), a tautomer or a stereoisomer thereof, or a salt thereof:

where: X1' is chlorine;
X2' is NH2;
X3' is a hydrogen atom; and
each of R1' and R2' is CH2OH.
[claim4]
4. A promoting agent having at least one function selected from the group consisting of an angiogenesis-promoting function, a lumen formation-promoting function, and a neurocyte growth-promoting function, the promoting agent comprising: the cyclobutyl purine derivative according to claim 2, the tautomer or the stereoisomer thereof, or the salt thereof.
[claim5]
5. A drug having at least one function selected from the group consisting of promoting angiogenesis, promoting lumen formation, and promoting neurocyte growth, the drug comprising: at least one compound selected from the group consisting of the cyclobutyl purine derivative according to claim 3, the tautomers and the stereoisomers thereof, the salts thereof and
at least, one pharmaceutically acceptable additive.
  • Inventor, and Inventor/Applicant
  • TSUKAMOTO IKUKO
  • KONISHI RYOJI
  • TOKUDA MASAAKI
  • KUBOTA YASUO
  • MARUYAMA TOKUMI
  • KOSAKA HIROAKI
  • IGARASHI JUNSUKE
  • KAGAWA UNIVERSITY
IPC(International Patent Classification)
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