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VACCINE FOR CRUSTACEAN ACUTE VIRAEMIA

外国特許コード F120006285
整理番号 A-021
掲載日 2012年3月6日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2010JP060503
国際公開番号 WO 2011004697
国際出願日 平成22年6月22日(2010.6.22)
国際公開日 平成23年1月13日(2011.1.13)
優先権データ
  • 特願2009-162802 (2009.7.9) JP
発明の名称 (英語) VACCINE FOR CRUSTACEAN ACUTE VIRAEMIA
発明の概要(英語) Disclosed is a vaccine effective for the prevention of crustacean acute viraemia. Specifically disclosed is a vaccine for preventing crustacean acute viraemia, which utilizes VP28 protein encoded by VP28 gene of a white-spot syndrome virus (WSSV) as an antigen.
従来技術、競合技術の概要(英語) BACKGROUND ART
Acute viremia of crustaceans (white spot syndrome, also referred to as diseases such as vitiligo) is, the most severe damage in farming of shellfish is viral disease have been reported. This disease is shown in a high lethality for several days from infection, resulting in effective prevention, treatment method has not been established. Therefore, the pathogenic virus is white spot syndrome virus (White Spot Syndrome Virus; WSSV) not brought into the farm, only this disease with respect to the effectiveness of the current being a measure. However, once the pathogenic virus and from entering in the farm, in order to clear the virus which are raised on only discards all crustaceans, very large economic losses. In this pathogenic virus WSSV is, has a wide host range crustaceans (non-patent document 1), genetic variation between isolates also are hardly observed (non-patent document 2) from, one 1 is at a close WSSV infection in crustaceans cultured expanded at once to a different type of crustaceans is a possibility that the high. Therefore, this disease convenience for the prevention of the development of more effectively been desired earnestly.
In the crustacean viral disease as a prophylactic, Patent Document 1 and 2 is, the structural proteins of WSSV as a vaccine, or encoding a structural protein such as a live attenuated bacterial or viral gene has been introduced as a vaccine, is administered a crustacean disclosed.
For aquatic animals as other antiviral agents, virus vector that encodes a protein as an active ingredient for promoting the development of vaccines has also been carried DNA (patent document 3). Does not have the infectious DNA vaccine, held for a long time in vivo humoral immune response and cell-mediated immune response that is capable of both, the manufacturing and storage is also easy. However DNA vaccine will be, by the method of administration to elicit an immune response cannot be effectively problems often arise.
In recent years, in order to enhance the immunostimulatory DNA in a vaccine, non-methylated CpG motif characteristic of bacteria (methylated cytosine and guanine-rich DNA sequence) is incorporated into a vector DNA as adjuvants known method (for example, the non-patent document 3 and patent document 3). In this method, non-methylated CpG motif is recognized by the TLR9 receptor, are drawn into a cell by the immune system, such as various inflammatory cytokine production of immune activation response is elicited, the immune response is believed to be enhanced. However non-methylated CpG motifs of immunostimulatory with an immunostimulatory sequence including for the function, many points are still unclear.
In order to solve the above-described problems, the inventors of the present invention, the gene encoding the viral structural proteins WSSV for mammalian expression vector is incorporated into the vector DNA made pTargeTTM DNA vaccine was administered to prawn, acute viremia WSSV very effectively prevent have found (patent document 4).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF MIYAZAKI
  • 発明者(英語)
  • SAKAI Masahiro
  • ITAMI Toshiaki
  • KONO Tomoya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

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