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Method for immobilizing self-organizing material or fine particle on substrate, and substrate manufactured by using such method

外国特許コード F120006299
整理番号 N051-10US1
掲載日 2012年3月12日
出願国 アメリカ合衆国
出願番号 92347010
公報番号 20110021381
公報番号 8372785
出願日 平成22年9月23日(2010.9.23)
公報発行日 平成23年1月27日(2011.1.27)
公報発行日 平成25年2月12日(2013.2.12)
国際出願番号 JP2005023981
国際公開番号 WO2006070841
国際出願日 平成17年12月27日(2005.12.27)
国際公開日 平成18年7月6日(2006.7.6)
優先権データ
  • 特願2004-381549 (2004.12.28) JP
  • 2005WO-JP23981 (2005.12.27) WO
  • 2007US-11819222 (2007.6.26) US
発明の名称 (英語) Method for immobilizing self-organizing material or fine particle on substrate, and substrate manufactured by using such method
発明の概要(英語) (US8372785)
A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized.
More specifically, the method for immobilizing the fine particles including a nucleic acid (for instance, DNA or RNA) or a metal oxide on the substrate, and the substrate whereupon the nucleic acid (for example, DNA or RNA) or the metal oxide is immobilized.
特許請求の範囲(英語) [claim1]
1. A method for immobilizing a self-organizing material on a substrate of metal oxide, comprising the steps of: applying to the substrate an acid solution capable of introducing a hydroxy group on a surface of the substrate; and
applying a solution containing the self-organizing material onto the substrate after the acid solution is removed from the substrate;
wherein the self-organizing material is a nucleic acid, a protein, an amino acid, a lipid, or a sugar.
[claim2]
2. The method as set forth in claim 1, wherein the metal oxide is Al2O3, ZnO, TiO2, SiO2, ZrO2, SrTiO2, LaAlO3, Y2O3, MgO, GGG, YIG, LiTaO, LiNbO, KTaO3, KNbO3, or NdGaO3.
[claim3]
3. The method as set forth in claim 1, further comprising the step of drying the self-organizing material-containing solution applied to the substrate.
[claim4]
4. The method as set forth in claim 3, wherein the drying step is performed by blowing a dry inert gas or air.
[claim5]
5. A substrate on which a self-organizing material is immobilized, the self-organizing material binding to a hydroxy group that has been formed on a surface of the substrate by acid treatment of the substrate, wherein the self-organizing material is a nucleic acid, a protein, an amino acid, a lipid, or a sugar.
[claim6]
6. The substrate as set forth in claim 5, wherein the substrate is a metal oxide selected from Al2O3, ZnO, TiO2, SiO2, ZrO2, SrTiO2, LaAlO3, Y2O3, MgO, GGG, YIG, LiTaO, LiNbO, KTaO3, KNbO3, or NdGaO3.
[claim7]
7. The substrate as set forth in claim 5, wherein the self-organizing material carries fine particles.
[claim8]
8. The substrate as set forth in claim 7, wherein the fine particles comprise gold, silver, platinum, palladium, iridium, rhodium, osmium, ruthenium, nickel, cobalt, indium, copper, TiO2, or BaTiO3.
[claim9]
9. The substrate as set forth in claim 7, wherein the fine particles have a particle diameter in a range of 1 nm to 100 nm.
[claim10]
10. The method as set forth in claim 1, wherein said acid solution consists of a mixture of hydrogen peroxide solution and hydrochloric acid solution.
[claim11]
11. The method as set forth in claim 1, wherein a hydroxy group is created on the surface of the substrate by applying the solution containing the self-organizing material onto the substrate.
[claim12]
12. The method as set forth in claim 11, wherein a self-organizing material is bonded directly to the substrate via the hydroxy group, the hydroxy group being created on the surface of the substrate by applying the solution containing the self-organizing material onto the substrate.
[claim13]
13. The substrate as set forth in claim 5, wherein said acid treatment is conducted by acid solution consisting of a mixture of hydrogen peroxide solution and hydrochloric acid solution.
[claim14]
14. The substrate as set forth in claim 13, wherein said self-organizing material is bonded directly to the substrate via the hydroxy group.
  • 発明者/出願人(英語)
  • KAWAI TOMOJI
  • TABATA HITOSHI
  • OTSUKA YOICHI
  • YAMADA FUMIHIKO
  • MATSUMOTO TAKUYA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • B01J019/00C
  • B82Y030/00
  • L01J219/00C10B2
  • L01J219/00C10B4
  • L01J219/00C4L12
  • L01J219/00C4L4B
参考情報 (研究プロジェクト等) CREST Creation of Novel Nano-material/System Synthesized by Self-organization for Medical Use AREA
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