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Method for immobilizing self-organizing material or fine particle on substrate, and substrate manufactured by using such method

Foreign code F120006299
File No. N051-10US1
Posted date Mar 12, 2012
Country United States of America
Application number 92347010
Gazette No. 20110021381
Gazette No. 8372785
Date of filing Sep 23, 2010
Gazette Date Jan 27, 2011
Gazette Date Feb 12, 2013
International application number JP2005023981
International publication number WO2006070841
Date of international filing Dec 27, 2005
Date of international publication Jul 6, 2006
Priority data
  • P2004-381549 (Dec 28, 2004) JP
  • 2005WO-JP23981 (Dec 27, 2005) WO
  • 2007US-11819222 (Jun 26, 2007) US
Title Method for immobilizing self-organizing material or fine particle on substrate, and substrate manufactured by using such method
Abstract (US8372785)
A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized.
More specifically, the method for immobilizing the fine particles including a nucleic acid (for instance, DNA or RNA) or a metal oxide on the substrate, and the substrate whereupon the nucleic acid (for example, DNA or RNA) or the metal oxide is immobilized.
Scope of claims [claim1]
1. A method for immobilizing a self-organizing material on a substrate of metal oxide, comprising the steps of: applying to the substrate an acid solution capable of introducing a hydroxy group on a surface of the substrate; and
applying a solution containing the self-organizing material onto the substrate after the acid solution is removed from the substrate;
wherein the self-organizing material is a nucleic acid, a protein, an amino acid, a lipid, or a sugar.
[claim2]
2. The method as set forth in claim 1, wherein the metal oxide is Al2O3, ZnO, TiO2, SiO2, ZrO2, SrTiO2, LaAlO3, Y2O3, MgO, GGG, YIG, LiTaO, LiNbO, KTaO3, KNbO3, or NdGaO3.
[claim3]
3. The method as set forth in claim 1, further comprising the step of drying the self-organizing material-containing solution applied to the substrate.
[claim4]
4. The method as set forth in claim 3, wherein the drying step is performed by blowing a dry inert gas or air.
[claim5]
5. A substrate on which a self-organizing material is immobilized, the self-organizing material binding to a hydroxy group that has been formed on a surface of the substrate by acid treatment of the substrate, wherein the self-organizing material is a nucleic acid, a protein, an amino acid, a lipid, or a sugar.
[claim6]
6. The substrate as set forth in claim 5, wherein the substrate is a metal oxide selected from Al2O3, ZnO, TiO2, SiO2, ZrO2, SrTiO2, LaAlO3, Y2O3, MgO, GGG, YIG, LiTaO, LiNbO, KTaO3, KNbO3, or NdGaO3.
[claim7]
7. The substrate as set forth in claim 5, wherein the self-organizing material carries fine particles.
[claim8]
8. The substrate as set forth in claim 7, wherein the fine particles comprise gold, silver, platinum, palladium, iridium, rhodium, osmium, ruthenium, nickel, cobalt, indium, copper, TiO2, or BaTiO3.
[claim9]
9. The substrate as set forth in claim 7, wherein the fine particles have a particle diameter in a range of 1 nm to 100 nm.
[claim10]
10. The method as set forth in claim 1, wherein said acid solution consists of a mixture of hydrogen peroxide solution and hydrochloric acid solution.
[claim11]
11. The method as set forth in claim 1, wherein a hydroxy group is created on the surface of the substrate by applying the solution containing the self-organizing material onto the substrate.
[claim12]
12. The method as set forth in claim 11, wherein a self-organizing material is bonded directly to the substrate via the hydroxy group, the hydroxy group being created on the surface of the substrate by applying the solution containing the self-organizing material onto the substrate.
[claim13]
13. The substrate as set forth in claim 5, wherein said acid treatment is conducted by acid solution consisting of a mixture of hydrogen peroxide solution and hydrochloric acid solution.
[claim14]
14. The substrate as set forth in claim 13, wherein said self-organizing material is bonded directly to the substrate via the hydroxy group.
  • Inventor, and Inventor/Applicant
  • KAWAI TOMOJI
  • TABATA HITOSHI
  • OTSUKA YOICHI
  • YAMADA FUMIHIKO
  • MATSUMOTO TAKUYA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation of Novel Nano-material/System Synthesized by Self-organization for Medical Use AREA
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