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Construction of protein-responsive shRNA/RNAi regulation system utilizing RNP motif

Foreign code F120006320
File No. I029P008WO
Posted date Mar 22, 2012
Country China
Application number 200980149535
Gazette No. 102245766
Gazette No. 102245766
Date of filing Dec 9, 2009
Gazette Date Nov 16, 2011
Gazette Date Oct 2, 2013
Priority data
  • P2008-312951 (Dec 9, 2008) JP
Title Construction of protein-responsive shRNA/RNAi regulation system utilizing RNP motif
Abstract

Disclosed is an RNAi regulation system utilizing an RNA-protein interaction motif. Specifically disclosed is shRNA which comprises a guide strand comprising a sequence complementary to a target sequence, a passenger strand capable of being annealed to the guide strand to form a double strand, and a linker strand capable of linking the guide strand to the passenger strand, wherein the linker strand comprises an RNP-derived protein-binding motif sequence. Also disclosed is an RNAi regulation system which comprises the shRNA and an RNP-derived protein capable of binding specifically to a protein-binding motif sequence in the shRNA.

  • Applicant
  • JAPAN SCIENCE & TECH AGENCY
  • Inventor
  • INOUE TAN,
  • SAITO HIROHIDE,
  • KASHIDA SHUNICHI,
  • HAYASHI KARIN
IPC(International Patent Classification)
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