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PRODUCTION OF ENTERITIS EVOKING CAUSAL FACTOR BY HIGHLY PATHOGENIC ORAL BACTERIA AND HIGH SENSITIVITY DETECTION METHOD THEREFOR UPDATE コモンズ 新技術説明会

外国特許コード F120006401
整理番号 0922
掲載日 2012年4月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP055688
国際公開番号 WO 2011111790
国際出願日 平成23年3月10日(2011.3.10)
国際公開日 平成23年9月15日(2011.9.15)
優先権データ
  • 特願2010-053079 (2010.3.10) JP
発明の名称 (英語) PRODUCTION OF ENTERITIS EVOKING CAUSAL FACTOR BY HIGHLY PATHOGENIC ORAL BACTERIA AND HIGH SENSITIVITY DETECTION METHOD THEREFOR UPDATE コモンズ 新技術説明会
発明の概要(英語) Disclosed is the construction of a system capable of quickly and easily identifying patients having a risk for worsening inflammatory digestive tract disease by identifying a causal factor for the worsening of the inflammatory digestive tract disease. Specifically disclosed is a method for detecting oral bacteria that cause worsening of inflammatory digestive tract disease and/or a screening that targets high risk for worsening of inflammatory digestive tract disease and/or determining the risk for worsening of the inflammatory digestive tract disease by PA not being detected and/or CBP being detected, inclusive of the detection of PA, which is an oral bacteria protein antigen, and/or CBP, which is collagen binding protein, in samples. Also disclosed are a detection reagent and kit used for this method.
従来技術、競合技術の概要(英語) BACKGROUND ART
(Inflammatory Bowel Disease, IBD) is inflammatory bowel disease, inflammatory bowel disease and chronic and refractory, mainly Crohn's disease and ulcerative colitis are classified. In regard to the number of patients with 2003 years (injuries is specified and therefore, the number of certified as a patient) is, ulcerative colitis: about 8 million, Crohn's disease: about 2 million person. However Japanese lifestyles is steadily increased by the number of patients and, in the year 2003 year 1980 (the number of patients about 5000 person) of 20 times. In the future, further Japanese diet also develop by younger expected user may be increased, to further increase the number of patients of question undoubtedly.
As a cause of the onset, genetic predisposition, high fat, high protein diet, abnormality of the immune system, intestinal bacteria, and the like is pointed out, is at risk of developing factors (risk factors) has not been elucidated. However the abnormality of the immune system plays an important role in the onset of the pathological condition being considered. The treatment methods include those that are established but, as a general therapy and dietary therapy rest, the steroid drug therapy, an immunosuppressive agent is administered, in addition to this sarazopirin, mesalazine, an antimicrobial agent such as, indicate that antibiotic effect. For these reasons, enteric bacteria are involved but it should be pointed out, the onset of a disease state specific enteric bacteria still connected to the convincing evidence that has not been shown in.
In recent years, a major pathogenic bacteria in the oral bacteria of caries, Streptococcus mutans (S. mutans) is one of S. mutans streptococci 1, bacteremia and endocarditis infection disease-also known as bacteria, in addition, bacteria from a specimen of the cardiac valve and aortic aneurysm detected s. mutans DNA from, cardiovascular disease and also the associations have been reported (non-patent document 1). However, the digestive tract such as inflammatory bowel disease involving oral bacterial inflammation has been reported that No.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
  • OSAKA UNIVERSITY
  • 発明者(英語)
  • UMEMURA, Kazuo
  • HOKAMURA, Kazuya
  • NAKANO, Kazuhiko
  • OOSHIMA, Takashi
  • NOMURA, Ryota
  • WADA, Koichiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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