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Analgesic agent comprising cyclic phosphatidic acid derivative achieved

Foreign code F120006423
File No. 06-0041US2
Posted date Apr 11, 2012
Country United States of America
Application number 90766610
Gazette No. 20110086820
Gazette No. 8017597
Date of filing Oct 19, 2010
Gazette Date Apr 14, 2011
Gazette Date Sep 13, 2011
International application number JP2007001463
International publication number WO2008081580
Date of international filing Dec 25, 2007
Date of international publication Jul 10, 2008
Priority data
  • P2006-353642 (Dec 28, 2006) JP
  • 2007WO-JP01463 (Dec 25, 2007) WO
  • 2009US-12447566 (Aug 18, 2009) US
Title Analgesic agent comprising cyclic phosphatidic acid derivative achieved
Abstract (US8017597)
An object of the present invention is to elucidate an analgesic effect as one of new cPA bioactivities and thus to provide a novel analgesic agent.
The present invention provides an analgesic agent which comprises a cyclic phosphatidic acid derivative that is one type of phospholipid.
Scope of claims [claim1]
1. A method of alleviating pain comprising administering an effective amount to a patient in need thereof, a compound represented by the formula (1):
wherein R represents C1-C30 linear or branched alkyl, C2-C30 linear or branched alkenyl, or C2-C30 linear or branched alkynl, provided that such groups are optionally substituted by a cycloalkane ring or an aromatic ring; X and Y each independently represents -- O -- or -- C2 -- , provided that X and Y do not simultaneously represent -- CH2 -- ; and M represents a hydrogen atom or a counter cation, or a pharmacologically acceptable salt thereof, to alleviate pain.
[claim2]
2. The method according to claim 1, wherein in the compound of formula (1), X and Y represent -- O -- .
[claim3]
3. The method according to claim 1, wherein in the compound of formula (1), X X or Y represents -- CH2 -- .
[claim4]
4. The method according to claim 1, wherein the compound of formula (1) is 1-oleoyl cyclic phosphatidic acid or 1-palmitoleoyl cyclic phosphatidic acid.
  • Inventor, and Inventor/Applicant
  • MUROFUSHI KIMIKO
  • KANASHIKI HARUMI
  • OCHANOMIZU UNIVERSITY
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • A61K031/665
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