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Akt activity specifically inhibiting polypeptide UPDATE 実績あり

外国特許コード F120006785
整理番号 Y0408WO
掲載日 2012年6月26日
出願国 アメリカ合衆国
出願番号 58305804
公報番号 20120034651
公報番号 8440630
出願日 平成16年12月14日(2004.12.14)
公報発行日 平成24年2月9日(2012.2.9)
公報発行日 平成25年5月14日(2013.5.14)
国際出願番号 JP2004018646
国際公開番号 WO2005056594
国際出願日 平成16年12月14日(2004.12.14)
国際公開日 平成17年6月23日(2005.6.23)
優先権データ
  • 特願2003-416556 (2003.12.15) JP
  • 特願2004-134583 (2004.4.28) JP
  • 2004WO-JP18646 (2004.12.14) WO
発明の名称 (英語) Akt activity specifically inhibiting polypeptide UPDATE 実績あり
発明の概要(英語) (US8440630)
The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like.
The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives.
Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides.
The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.
特許請求の範囲(英語) [claim1]
1. An isolated polypeptide that specifically inhibits Akt activity consisting of: an amino acid sequence indicated in SEQ ID NO: 1 or 20 of the sequence listing.
[claim2]
2. A composition for inhibiting Akt activity, comprising: the isolated polypeptide according to claim 1 as an active ingredient.
[claim3]
3. A method for inhibiting Act activity in a cell, comprising contacting the cell with the composition according to claim 2, wherein specific inhibition of Akt activity in the cell is the inhibition of binding of phosphoinositide to Akt.
[claim4]
4. A method for treating breast cancer comprising administering to a patient in need thereof a composition of claim 2.
[claim5]
5. A method for treating lung cancer comprising administering to a patient in need thereof a composition of claim 2.
[claim6]
6. A method for treating leukemia comprising administering to a patient in need thereof a composition of claim 2.
[claim7]
7. A method for treating lymphoid tumor comprising administering to a patient in need thereof a composition of claim 2.
[claim8]
8. The composition of claim 2, further comprising a pharmaceutical carrier.
  • 発明者/出願人(英語)
  • NOGUCHI MASAYUKI
  • OKADA FUTOSHI
  • HIROMURA MAKOTO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
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