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Akt activity specifically inhibiting polypeptide achieved

Foreign code F120006785
File No. Y0408WO
Posted date Jun 26, 2012
Country United States of America
Application number 58305804
Gazette No. 20120034651
Gazette No. 8440630
Date of filing Dec 14, 2004
Gazette Date Feb 9, 2012
Gazette Date May 14, 2013
International application number JP2004018646
International publication number WO2005056594
Date of international filing Dec 14, 2004
Date of international publication Jun 23, 2005
Priority data
  • P2003-416556 (Dec 15, 2003) JP
  • P2004-134583 (Apr 28, 2004) JP
  • 2004WO-JP18646 (Dec 14, 2004) WO
Title Akt activity specifically inhibiting polypeptide achieved
Abstract (US8440630)
The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like.
The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives.
Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides.
The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.
Scope of claims [claim1]
1. An isolated polypeptide that specifically inhibits Akt activity consisting of: an amino acid sequence indicated in SEQ ID NO: 1 or 20 of the sequence listing.
[claim2]
2. A composition for inhibiting Akt activity, comprising: the isolated polypeptide according to claim 1 as an active ingredient.
[claim3]
3. A method for inhibiting Act activity in a cell, comprising contacting the cell with the composition according to claim 2, wherein specific inhibition of Akt activity in the cell is the inhibition of binding of phosphoinositide to Akt.
[claim4]
4. A method for treating breast cancer comprising administering to a patient in need thereof a composition of claim 2.
[claim5]
5. A method for treating lung cancer comprising administering to a patient in need thereof a composition of claim 2.
[claim6]
6. A method for treating leukemia comprising administering to a patient in need thereof a composition of claim 2.
[claim7]
7. A method for treating lymphoid tumor comprising administering to a patient in need thereof a composition of claim 2.
[claim8]
8. The composition of claim 2, further comprising a pharmaceutical carrier.
  • Inventor, and Inventor/Applicant
  • NOGUCHI MASAYUKI
  • OKADA FUTOSHI
  • HIROMURA MAKOTO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
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