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IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT commons

Foreign code F120006792
File No. NU-0456
Posted date Jun 27, 2012
Country WIPO
International application number 2012JP055679
International publication number WO 2012/121248
Date of international filing Mar 6, 2012
Date of international publication Sep 13, 2012
Priority data
  • P2011-052572 (Mar 10, 2011) JP
Title IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT commons
Abstract

A method for highly enantio-selectively producing an optically active spirolactone compound using a iodoarene derivative which can be easily synthesized and scarcely racemized. From 2,6-dihydroxyiodoarene, a flexibly designable hypervalent iodine compound precursor (a iodoarene derivative) is synthesized in short steps using 1,2-amino alcohol as a chiral source. Using a catalytic amount of the precursor, a hypervalent iodine compound is prepared in situ in the presence of a stoichiometric amount of m-CPBA, and 3-(1-hydroxy-2-naphthyl)propionic acid is subjected to spirolactonization. As a result, a corresponding spirolactone compound can be obtained with a high enantiomer excess.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY,
  • ISHIHARA, KAZUAKI,
  • UYANIK, MUHAMMET,
  • YASUI, TAKESHI
  • Inventor
  • ISHIHARA, KAZUAKI,
  • UYANIK, MUHAMMET,
  • YASUI, TAKESHI
IPC(International Patent Classification)
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