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METHOD FOR SELECTING IPS CELL CLONE, AND METHOD FOR SELECTING GENE USED IN METHOD FOR SELECTING SAME

Foreign code F120006842
File No. S2011-0509
Posted date Sep 14, 2012
Country WIPO
International application number 2012JP054800
International publication number WO 2012/115270
Date of international filing Feb 27, 2012
Date of international publication Aug 30, 2012
Priority data
  • P2011-040979 (Feb 25, 2011) JP
  • 201161466298P (Mar 22, 2011) US
Title METHOD FOR SELECTING IPS CELL CLONE, AND METHOD FOR SELECTING GENE USED IN METHOD FOR SELECTING SAME
Abstract

The purpose of the present invention is to provide a method for selecting an iPS cell clone with which tumor formation is less likely even when caused to differentiate, and a method for selecting a gene used in the method for selecting the same. As one embodiment, the expression level is examined with regards to at least one gene in any gene group from among first through tenth gene groups in an iPS cell clone in an undifferentiated state, whereby there is selected an iPS cell clone in which tumor formation is less likely even when caused to differentiate. Also, the expression level of a gene belonging to a candidate gene group including one or more genes is examined in each iPS clone in an undifferentiated state in relation to a plurality of first iPS cell clones that cannot differentiate normally or that are likely to form a tumor when differentiated and a plurality of second iPS cell clones that are less likely to form a tumor, whereby there is selected a gene used in the method for selecting an iPS cell clone with which tumor formation is less likely even when caused to differentiate.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KEIO UNIVERSITY,
  • OKADA, YOHEI,
  • OKANO, HIDEYUKI,
  • TSUNODA, TATSUHIKO,
  • MIYA, FUYUKI
  • Inventor
  • OKADA, YOHEI,
  • OKANO, HIDEYUKI,
  • TSUNODA, TATSUHIKO,
  • MIYA, FUYUKI
IPC(International Patent Classification)
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