METHOD FOR SCREENING BINDING INHIBITOR OF RAGE AND AGE
Provided is a method for screening a binding inhibitor of RAGE and AGE focused on the new activity of ss-amyloid peptide. Provided is a method for screening a binding inhibitor of RAGE and AGE by sorting candidate compounds inhibiting the activity affecting the binding affinity of RAGE and AGE of ss-amyloid peptide through finding, for the first time, that the ss-amyloid peptide makes the binding of RAGE and AGE change to high binding affinity. The binding inhibitor obtained by this screening method can be used as a therapeutic agent for any diseases or symptoms caused by the binding of RAGE and AGE in which ss-amyloid peptide involves. Especially, the binding inhibitor is capable of contributing to the development of the therapeutic drug for Alzheimer's disease focused on the new mechanism.