TOP > 外国特許検索 > STABLE ISOTOPE-LABELED AMINO ACID, METHOD OF INTEGRATING THE SAME INTO TARGET PROTEIN, METHOD OF NMR STRUCTURAL ANALYSIS OF PROTEIN AND PROCESS FOR PRODUCING SITE-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID

STABLE ISOTOPE-LABELED AMINO ACID, METHOD OF INTEGRATING THE SAME INTO TARGET PROTEIN, METHOD OF NMR STRUCTURAL ANALYSIS OF PROTEIN AND PROCESS FOR PRODUCING SITE-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID

外国特許コード F040000708
整理番号 (A021P55)
掲載日 2005年4月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2002JP013303
国際公開番号 WO 2003/053910
国際出願日 平成14年12月19日(2002.12.19)
国際公開日 平成15年7月3日(2003.7.3)
優先権データ
  • 特願2001-386823 (2001.12.19) JP
  • 特願2002-022446 (2002.1.30) JP
発明の名称 (英語) STABLE ISOTOPE-LABELED AMINO ACID, METHOD OF INTEGRATING THE SAME INTO TARGET PROTEIN, METHOD OF NMR STRUCTURAL ANALYSIS OF PROTEIN AND PROCESS FOR PRODUCING SITE-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID
発明の概要(英語) It is intended to provide a stable isotope-labeled amino acid which is at least one of amino acids constituting protein, characterized by having at least one of the following labeling patterns: (a) in one or more methylene groups, methylene hydrogen atoms other than at least one have been deuterated; (b) in prochiral gem-methyl groups, hydrogen atoms in one of the methyl groups have been completely deuterated; (c) in prochiral gem-methyl groups, hydrogen atoms in the methyl groups have been partially deuterated; and (d) hydrogen atoms in a methyl group other than one have been deuterated while hydrogen atoms in an aromatic ring have been partially deuterated. Using this stable isotope-labeled amino acid, deuterium substitution of a protein can be achieved without worsening the NMR sensitivity of the residual hydrogen nucleus. Thus, an NMR spectrum of a high-molecular weight protein exceeding the upper limit applicable in the prior art can be quickly and surely analyzed and the stereostructure can be highly precisely determined at the same time.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Japan Science And Technology Corporation
  • 発明者(英語)
  • Kainosho, Masatsune
  • Terauchi, Tsutomu
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Genetic Programming AREA
ライセンスをご希望の方、特許の内容に興味を持たれた方は、問合せボタンを押してください。

PAGE TOP

close
close
close
close
close
close