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METHOD FOR ANALYZING MUCIN 1 USING PROBE CAPABLE OF BINDING TO 3´-SULFONATED CORE 1 CARBOHYDRATE CHAIN, AND METHOD FOR DETECTING OR MONITORING BREAST CANCER

外国特許コード F130007099
整理番号 S2011-0654-N0
掲載日 2013年1月9日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP065360
国際公開番号 WO 2012173228
国際出願日 平成24年6月15日(2012.6.15)
国際公開日 平成24年12月20日(2012.12.20)
優先権データ
  • 特願2011-134350 (2011.6.16) JP
発明の名称 (英語) METHOD FOR ANALYZING MUCIN 1 USING PROBE CAPABLE OF BINDING TO 3´-SULFONATED CORE 1 CARBOHYDRATE CHAIN, AND METHOD FOR DETECTING OR MONITORING BREAST CANCER
発明の概要(英語) The purpose of the present invention is to provide a method for detecting even mucin 1 derived from breast cancer, which cannot be detected by a CA15-3 measurement method. The purpose can be achieved by a method for analyzing mucin 1 having a Sulfo-3Galβ1-3GalNAc-R carbohydrate chain, characterized by comprising: a step of bringing a 3´-sulfonated core 1 carbohydrate chain binding probe capable of binding to the Sulfo-3Galβ1-3GalNAc-R carbohydrate chain into contact with a sample to be tested; a step of bringing a 3´-sulfonated core 1 carbohydrate chain mucin 1 peptide binding probe capable of binding to mucin 1 having the Sulfo-3Galβ1-3GalNAc-R carbohydrate chain or a mucin 1 binding probe capable of binding to mucin 1 into contact with the sample; and a step of detecting a bonded product of mucin 1 having the Sulfo-3Galβ1-3GalNAc-R carbohydrate chain and the probes.
従来技術、競合技術の概要(英語) BACKGROUND ART
Women's breast cancer is at position 4, the age of 65 years of age 30 insofar as, a cancer of the female in the second position 1. Japanese female breast in particular recently has increased, the number of the year 4 a new patient is said to be more than ten million individuals.
The clinical test item CA15-3, and used as a marker of breast cancer, the degree of malignancy of breast cancer, as well as the index of the degree of progress, and are useful as monitoring of therapeutic effect (Non-Patent Document 1). CA15-3 is, human milk fat globules glycoprotein on the membrane (115D8) a monoclonal antibody against the MAM-6 (Non-Patent Document 2) and breast cancer (DF3) monoclonal antibodies against the liver tissue (Non-Patent Document 3) by using the immunoassay (sandwich method) has been detected. Detected by the immunoassay method of this CA15-3 to the antigen, a mucin derived from an epithelial cell is the extracellular domain of 1. However, the CA15-3, the prognosis of a breast useful for tracking, sensitivity is low, and thus all breast cancer in the patient as low as 15% positive rate, has limited its applications.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • YAMAGUCHI UNIVERSITY
  • 発明者(英語)
  • YAMASHITA Katsuko
  • IDEO Hiroko
  • HINODA Yuji
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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