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METHOD FOR ASSESSING BREAST CANCER SUSCEPTIBILITY

Foreign code F130007113
File No. S2011-0010-C0
Posted date Jan 11, 2013
Country WIPO
International application number 2011JP005983
International publication number WO 2012/056694
Date of international filing Oct 26, 2011
Date of international publication May 3, 2012
Priority data
  • P2010-240189 (Oct 26, 2010) JP
Title METHOD FOR ASSESSING BREAST CANCER SUSCEPTIBILITY
Abstract

The present invention addresses the problem of providing a method for identifying the DNA copy number variation relating to breast cancer susceptibility and assessing breast cancer susceptibility on the basis of an increase or decrease in this DNA copy number variation. The problem is solved by performing microarray analysis using the peripheral blood of a sporadic breast cancer patient, identifying the DNA copy number variation relating to breast cancer susceptibility in a chromosomal region, detecting the number of copies of this DNA copy number variation by quantitative PCR, and thereby assessing breast cancer susceptibility from the increase or decrease in the DNA copy number variation. Furthermore, it is possible to improve the accuracy of the breast cancer susceptibility assessment by detecting the DNA copy number variation using the above-mentioned quantitative PCR in which two or more chromosomal regions have been selected and performing discriminant analysis on the basis of that result.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • YAMAGUCHI UNIVERSITY,
  • SUEHIRO, YUTAKA,
  • SASAKI, KOHSUKE,
  • HINODA, YUJI,
  • OKADA, TAKAE
  • Inventor
  • SUEHIRO, YUTAKA,
  • SASAKI, KOHSUKE,
  • HINODA, YUJI,
  • OKADA, TAKAE
IPC(International Patent Classification)

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