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METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND OR SALT THEREOF

Foreign code F130007158
File No. S2012-0957-N0
Posted date Feb 8, 2013
Country WIPO
International application number 2012JP052176
International publication number WO 2012/105574
Date of international filing Jan 31, 2012
Date of international publication Aug 9, 2012
Priority data
  • P2011-153342 (Jul 11, 2011) JP
  • P2011-019287 (Jan 31, 2011) JP
  • P2011-153692 (Jul 12, 2011) JP
Title METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND OR SALT THEREOF
Abstract

Provided is a production method in which optically active oxazoline is synthesized with fewer production steps using a compound having no optical activity as a starting material compound. A method for producing an optically active compound represented by formula (3) (wherein * represents an asymmetric carbon atom) or a salt thereof, characterized by cyclizing a compound represented by formula (1) (wherein R1 represents an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, wherein an arbitrary hydrogen atom of such a group may be substituted by a substituent, and R2 represents a hydrogen atom or a group which does not take part in the reaction) in the presence of an asymmetric ligand having one or more coordination sites, a Lewis acid represented by formula (2): MmZn (wherein M represents a metal ion, Z represents a counter anion to M, and m and n represents an integer of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NAGASAKI UNIVERSITY,
  • NAGASE CHEMTEX CORPORATION,
  • ONOMURA, OSAMU,
  • TSUDA, YUTARO,
  • KURIYAMA, MASAMI,
  • YANAGI, TOSHIHARU,
  • KODAMA, KAZUYA
  • Inventor
  • ONOMURA, OSAMU,
  • TSUDA, YUTARO,
  • KURIYAMA, MASAMI,
  • YANAGI, TOSHIHARU,
  • KODAMA, KAZUYA
IPC(International Patent Classification)
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