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POLYPEPTIDE FOR DISTINGUISHING SILICON OXIDE FROM SILICON NITRIDE, AND USE THEREOF

外国特許コード F130007169
整理番号 S2011-0267-C0
掲載日 2013年2月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP079501
国際公開番号 WO 2012090789
国際出願日 平成23年12月20日(2011.12.20)
国際公開日 平成24年7月5日(2012.7.5)
優先権データ
  • 特願2010-292975 (2010.12.28) JP
発明の名称 (英語) POLYPEPTIDE FOR DISTINGUISHING SILICON OXIDE FROM SILICON NITRIDE, AND USE THEREOF
発明の概要(英語) The present invention provides a technique by which it is possible to distinguish a silicon oxide from a silicon nitride. More specifically, the present invention provides a first polypeptide which bonds specifically to silicon oxide and does not bond to silicon nitride, and/or provides a second polypeptide which bonds specifically to silicon nitride and does not bond to silicon oxide. Further provided is a composition that contains the first polypeptide and/or the second polypeptide. Furthermore, the present invention provides a substrate having a surface that bonds to the first polypeptide and/or the second polypeptide, and a semiconductor device provided with the substrate.
従来技術、競合技術の概要(英語) BACKGROUND ART
In recent years, biotechnology and nanotechnology is the fusion of the birth of a new region that nano-biotechnology area, is being rapidly developed. Nano-biotechnology is, for example, the fabrication of biosensors and bio-organic electronic element, a target DNA or protein used as a development of the biochip and, very large expectation nano-biotechnology.
As described above, in nano-biotechnology, biosensors and bio-organic electronic element is critical to the technique, the DNA chip or a protein chip has attracted attention. In these chips, such as for example DNA or protein 1 for molecular sensing is performed by considering the size of the molecule so that the control is essential for the preparation of the sensor. Therefore, the semiconductor processing technique using development of bio-sensors is provided.
Specifically, for example, silicon nanowires on the immobilized antibodies against the virus to be detected, if even one virus binds to the antibody 1, can be electrically detected such as, advances with respect to the development of bio-sensors.
In this way, the semiconductor processing technique using the biosensor in order to further accelerate the development of, such as silicon or glass substrate (support) on a desired protein easily and accurately positioned, the immobilization techniques have been developed and is considered to be essential.
9 () four arginine residues added to the protein, while maintaining the enzyme activity on the glass surface can be directly adsorbed to the resin or silica have been reported (see non-patent document 1). Of the non-patent document 1 is added to the protein adsorbed to the silica techniques for, extended incubation of proteins by farther away from the silica surface, there is a problem that the suction force.
The biosensor is, high sensitivity can be detected rapidly and inexpensively be over multiple items, being spotlighted. As one of these, biomolecules such as enzyme-linked antibody fuzed and the semiconductor device is nano-devices have been proposed. A semiconductor device with a biomolecule which integrated using nano-devices in the development, the intended position in the protein on the device to precisely place technique is required.
Mainstream silicon semiconductor device (insulating film) as the major surface of the material, the oxide film (silicon oxide/SiO2) and the nitride film (silicon nitride/Si3 N4) is a general-purpose. Silicon oxide and silicon nitride if there is a technique which can identify, both silicon oxide and silicon nitride as an insulating film on the device by providing a patterned into a desired shape, the intended position in the protein on the device can be considered to be patterned.
The inventors of the present invention, a high suction force for a substance containing silicon oxide and specific binding are utilized, without modifying any glass surface, immobilized protein directly onto a glass substrate to develop a technique (see Patent Document 1). According to the present technique, a protein chip may be fabricated very is high. In addition, the protein can be bound to a silicon oxide have been reported (see non-patent document 3).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Hiroshima University
  • 発明者(英語)
  • IKEDA, Takeshi
  • MOTOMURA, Kei
  • KURODA, Akio
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

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