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Heparin-Binding Protein Having Heparan Sulfate Sugar Chain Attached Thereto Process For Producing The Same And Medicinal Composition Containing The Same

Foreign code F130007237
File No. 2006003229
Posted date Mar 27, 2013
Country United Kingdom of Great Britain and Northern Ireland
Application number 0621466
Gazette No. 2427863
Gazette No. 2427863
Date of filing Mar 31, 2005
Gazette Date Jan 10, 2007
Gazette Date Dec 17, 2008
Priority data
  • P2004-108570 (Mar 31, 2004) JP
Title Heparin-Binding Protein Having Heparan Sulfate Sugar Chain Attached Thereto Process For Producing The Same And Medicinal Composition Containing The Same
Abstract

A cDNA encoding a peptide capable of having selective heparan sulfate-attachment is bonded to another cDNA encoding a heparin-binding protein and the gene product of this bonded cDNA is produced by animal cells, thereby producing a heparin-binding protein having a heparan sulfate sugar chain attached via a covalent bond in its molecule. Because of having a sulfated glycosaminoglycan sugar chain with little chondroitin sulfate covalently bonded thereto, this heparin-binding protein having a heparan sulfate sugar chain attached thereto has high functions such as being stable to, for example, heat, acids, alkalis and so on in vivo, is effective in cell growth, tissue regeneration and so on, and, moreover, has an effect of controlling the physiological function of FGF. Thus, it is highly useful as a drug for preventing and treating various diseases in which FGF participates.

  • Applicant
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY
  • Inventor
  • TORU IMAMURA,
  • MASAHIRO ASADA,
  • MASASHI SUZUKI
IPC(International Patent Classification)

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