Top > Search of International Patents > BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, ss-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER

BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, ss-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER

Foreign code F130007252
Posted date Apr 2, 2013
Country WIPO
International application number 2006JP312806
International publication number WO 2007/000998
Date of international filing Jun 27, 2006
Date of international publication Jan 4, 2007
Priority data
  • P2005-187394 (Jun 27, 2005) JP
Title BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, ss-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER
Abstract

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the proliferation of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a carcinogenesis-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a carcinogenesis-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and carcinogenesis-preventive activity can be synthesized.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TOHOKU UNIVERSITY,
  • SHIBATA, HIROYUKI,
  • IWABUCHI, YOSHIHARU,
  • OHORI, HISATSUGU,
  • YAMAGOSHI, HIROYUKI,
  • KAKUDO, YUICHI
  • Inventor
  • SHIBATA, HIROYUKI,
  • IWABUCHI, YOSHIHARU,
  • OHORI, HISATSUGU,
  • YAMAGOSHI, HIROYUKI,
  • KAKUDO, YUICHI
IPC(International Patent Classification)
Please contact us by facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close