TOP > 外国特許検索 > ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME

ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME

外国特許コード F130007277
整理番号 S2011-1188-N0
掲載日 2013年4月5日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP072774
国際公開番号 WO 2013035799
国際出願日 平成24年9月6日(2012.9.6)
国際公開日 平成25年3月14日(2013.3.14)
優先権データ
  • 特願2011-194323 (2011.9.6) JP
  • 特願2012-077774 (2012.3.29) JP
発明の名称 (英語) ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME
発明の概要(英語) The present invention provides: a measurement method and a measurement reagent both improved in accuracy and a method for improving measurement accuracy, all of which are used in the measurement of periostin contained in a sample; and a method for detecting pulmonary fibrosis or interstitial pneumonia, which is improved in accuracy. An antibody according to the present invention can bind to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region and an R3 region of periostin or a decomposition product thereof. All of a method and a reagent both for measuring periostin and a method for improving the accuracy of the measurement of periostin according to the present invention are characterized in that at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region and an R3 region of periostin is detected. A method for detecting pulmonary fibrosis or interstitial pneumonia according to the present invention comprises: a) a step of measuring the amount or concentration of periostin in a sample from a subject, wherein at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region and an R3 region of periostin is detected; and b) a step of comparing the amount or concentration of periostin in the sample from the subject with that in a sample from a living organism which is not affected by either pulmonary fibrosis or interstitial pneumonia.
従来技術、競合技術の概要(英語) BACKGROUND ART
Is a fibroblast, and extracellular matrix proteins, gradually in the order C terminal side than the N-terminal side thereof, EMI region, R1 region, R2 region, R3 region, R4 region and the C-terminal region than would be the case, in the present invention is that one of the izuhara, measuring the level of expression of the gene to a fibroblast in an allergic disorder found to be useful as an inspection method, the inspection method of allergic diseases and completion of the present invention (see patent document 1 and non-patent document 1.). In addition, is izuhara, measuring the level of expression of the gene to a fibroblast in idiopathic interstitial pneumonia are also useful as an inspection method was found to be (see Patent Document 2.).
It should be noted that, in addition to, a polyclonal antibody against OSF2 (fibroblast), and diagnostic methods using an antibody of a monoclonal antibody have been disclosed (see Patent Document 3.), Termed Osf2/Cbfa1 new osteogenic cell specific transcription factors (fibroblast) to measure the anti-OSF2 antibody immunoassay is disclosed (see Patent Document 4.), And a purified antibody which binds specifically with a this antibody can be used to examine breast cancer metastasis to bone in the diagnostic assays is disclosed (see Patent Document 5.), Then, anti-cell adhesion activity using antibodies and the antibody to a fibroblast to a fibroblast disclosed methods for the determination of the like (see Patent Document 6.).
However, these types of useful in the diagnosis of such a fibroblast in measurement of the, other diseases of affected individuals and healthy person for paper currency, such as the sensitivity and specificity is improved accuracy has been desired.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SHINO-TEST CORPORATION
  • SAGA UNIVERSITY
  • KURUME UNIVERSITY
  • 発明者(英語)
  • IZUHARA Kenji
  • OHTA Shoichiro
  • ARIMA Kazuhiko
  • SHIRAISHI Hiroshi
  • SUZUKI Shoichi
  • HOSHINO Tomoaki
  • AZUMA Yoshinori
  • ONO Junya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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